Samsca and Polyuria - a phase IV clinical study of FDA data
Summary:
Polyuria is reported as a side effect among people who take Samsca (tolvaptan), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Hyponatremia.
The phase IV clinical study analyzes which people have Polyuria when taking Samsca. It is created by eHealthMe based on reports of 8,134 people who have side effects when taking Samsca from the FDA, and is updated regularly.
What is Samsca?
Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.
What is Polyuria?
Polyuria (production of too much dilute urine) is found to be associated with 1,699 drugs and 1,275 conditions by eHealthMe. Check the latest studies of Polyuria.
8,134 people reported to have side effects when taking Samsca.
Among them, 62 people (0.76%) have Polyuria.

Among these 62 people:
How long have people been on Samsca when they have Polyuria? *
What is the gender of people who have Polyuria when taking Samsca? *
What is the age of people who have Polyuria when taking Samsca? *
What are other drugs people take besides Samsca? *
What are other side effects people have besides Polyuria? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Samsca and have Polyuria?
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Related studies:
Effectiveness of, long term effects of, and alternative drugs to Samsca:
- Samsca (8,139 reports)
Polyuria treatments and more:
- Polyuria (15,800 reports)
How severe was Polyuria and when was it recovered:
Expand to all the drugs that have ingredients of tolvaptan:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Common Samsca side effects:
- Samsca side effect: Renal impairment (severely reduced kidney function) (468 reports)
- Samsca side effect: Hypernatraemia (an abnormally high plasma concentration of sodium ions) (413 reports)
- Samsca side effect: Dehydration (dryness resulting from the removal of water) (330 reports)
- Samsca side effect: Diarrhea (318 reports)
Browse all side effects of Samsca:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon drugs associated with Polyuria:
- Metformin side effect: Polyuria (823 reports)
- Omeprazole side effect: Polyuria (619 reports)
- Aspirin side effect: Polyuria (561 reports)
- Furosemide side effect: Polyuria (538 reports)
- Amlodipine side effect: Polyuria (391 reports)
- Prednisone side effect: Polyuria (387 reports)
- Lasix side effect: Polyuria (386 reports)
- Pantoprazole side effect: Polyuria (378 reports)
- Ibu side effect: Polyuria (354 reports)
- Ibuprofen side effect: Polyuria (353 reports)
Browse all the drugs that are associated with Polyuria:
- Polyuria (1,699 drugs)
Common conditions associated with Polyuria:
- Hypertension: 803 reports
- Hbp: 794 reports
- Diabetes - type 2: 515 reports
- Diabetes mellitus: 400 reports
- Diabetes: 396 reports
- Congenital cystic kidney disease: 324 reports
- Heartburn: 281 reports
- Depression: 267 reports
- Antidepressant therapy: 265 reports
- Pain: 263 reports
Browse all the conditions that are associated with Polyuria:
- Polyuria (1,275 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on tolvaptan (the active ingredients of Samsca) and Samsca (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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