Sandimmune and Icterus - a phase IV clinical study of FDA data

Summary:

Icterus is reported as a side effect among people who take Sandimmune (cyclosporine), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Methotrexate, and have Gastric ulcer perforation.

The phase IV clinical study analyzes which people have Icterus when taking Sandimmune. It is created by eHealthMe based on reports of 6,679 people who have side effects when taking Sandimmune from the FDA, and is updated regularly.

What is Sandimmune?

Sandimmune has active ingredients of cyclosporine. eHealthMe is studying from 6,694 Sandimmune users. Check the latest studies of Sandimmune.

What is Icterus?

Icterus (yellowish pigmentation of the skin) is found to be associated with 1,975 drugs and 3,029 conditions by eHealthMe. Check the latest studies of Icterus.

On Jun, 16, 2026

6,679 people reported to have side effects when taking Sandimmune.
Among them, 47 people (0.7%) have Icterus.

Among these 47 people:

How long have people been on Sandimmune when they have Icterus? *

What is the gender of people who have Icterus when taking Sandimmune? *

female: 61.54 %
male: 38.46 %

What is the age of people who have Icterus when taking Sandimmune? *

What are other drugs people take besides Sandimmune? *

What are other side effects people have besides Icterus? *

Blood Bilirubin Increased: 23 people, 48.94%
Fever: 17 people, 36.17%
Alanine Aminotransferase Increased: 12 people, 25.53%
Aspartate Aminotransferase Increased: 12 people, 25.53%
Hypotension (abnormally low blood pressure): 9 people, 19.15%
Rashes (redness): 9 people, 19.15%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 8 people, 17.02%
Pneumonia: 8 people, 17.02%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 7 people, 14.89%
Diarrhea: 7 people, 14.89%

What are the existing conditions these people have? *

Thrombocytopenia (decrease of platelets in blood): 3 people, 6.38%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 6.38%
Aplasia (defective development or congenital absence of an organ or tissue): 3 people, 6.38%
Gastric Ulcer Perforation (stomach hole due to ulcer): 3 people, 6.38%
Venoocclusive Liver Disease (small veins in the liver are obstructed): 2 people, 4.26%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 2 people, 4.26%
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 2 people, 4.26%
Gastric Ulcer (stomach ulcer): 2 people, 4.26%
Immunodeficiency Disorders: 2 people, 4.26%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 4.26%

* Approximation only. Some reports may have incomplete information.

Do you take Sandimmune and have Icterus?

- Check whether Icterus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sandimmune:

Sandimmune (6,694 reports)

Icterus treatments and more:

Icterus (33,621 reports)

Browse all side effects of Sandimmune:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Icterus:

Icterus (1,975 drugs)

Browse all the conditions that are associated with Icterus:

Icterus (3,029 conditions)

Related publications that referenced our studies

O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on cyclosporine (the active ingredients of Sandimmune) and Sandimmune (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.