Santyl and Burning sensation - a phase IV clinical study of FDA data

Summary:

Burning sensation is reported as a side effect among people who take Santyl (collagenase), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Polycythaemia vera.

The phase IV clinical study analyzes which people have Burning sensation when taking Santyl. It is created by eHealthMe based on reports of 1,473 people who have side effects when taking Santyl from the FDA, and is updated regularly.

What is Santyl?

Santyl has active ingredients of collagenase. eHealthMe is studying from 1,479 Santyl users. Check the latest studies of Santyl.

What is Burning sensation?

Burning sensation is found to be associated with 2,015 drugs and 2,077 conditions by eHealthMe. Check the latest studies of Burning sensation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,473 people reported to have side effects when taking Santyl.
Among them, 45 people (3.05%) have Burning sensation.

Among these 45 people:

How long have people been on Santyl when they have Burning sensation? *

What is the gender of people who have Burning sensation when taking Santyl? *

female: 80.56 %
male: 19.44 %

What is the age of people who have Burning sensation when taking Santyl? *

What are other drugs people take besides Santyl? *

What are other side effects people have besides Burning sensation? *

Pain: 18 people, 40.00%
Itching: 13 people, 28.89%
Impaired Healing: 13 people, 28.89%
Skin Ulcer: 13 people, 28.89%
Therapeutic Response Decreased (less preventive response): 12 people, 26.67%
White Blood Cell Count Increased: 12 people, 26.67%
Abnormal Behavior: 12 people, 26.67%
Head Injury: 12 people, 26.67%
Fatigue (feeling of tiredness): 12 people, 26.67%
Platelet Count Increased: 12 people, 26.67%

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 12 people, 26.67%
Wound: 8 people, 17.78%
Skin Ulcer: 5 people, 11.11%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 4.44%
Diabetes: 2 people, 4.44%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 4.44%
Thermal Burn (burn by heat): 1 person, 2.22%
Pressure Ulcer: 1 person, 2.22%
Pain: 1 person, 2.22%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 1 person, 2.22%

* Approximation only. Some reports may have incomplete information.

Do you take Santyl and have Burning sensation?

- Check whether Burning sensation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Santyl:

Santyl (1,479 reports)

Browse all side effects of Santyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Burning sensation:

Burning sensation (2,015 drugs)

Browse all the conditions that are associated with Burning sensation:

Burning sensation (2,077 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on collagenase (the active ingredients of Santyl) and Santyl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.