Saphris and Fever - a phase IV clinical study of FDA data

Summary:

Fever is reported as a side effect among people who take Saphris (asenapine maleate), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Tylenol, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Fever when taking Saphris. It is created by eHealthMe based on reports of 8,449 people who have side effects when taking Saphris from the FDA, and is updated regularly.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

What is Fever?

Fever is found to be associated with 3,494 drugs and 6,196 conditions by eHealthMe. Check the latest studies of Fever.

On Jul, 18, 2026

8,449 people reported to have side effects when taking Saphris.
Among them, 62 people (0.73%) have Fever.

Among these 62 people:

How long have people been on Saphris when they have Fever? *

What is the gender of people who have Fever when taking Saphris? *

female: 69.49 %
male: 30.51 %

What is the age of people who have Fever when taking Saphris? *

What are other drugs people take besides Saphris? *

What are other side effects people have besides Fever? *

Dyspnea (difficult or laboured breathing): 12 people, 19.35%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 12 people, 19.35%
Rashes (redness): 12 people, 19.35%
Diarrhea: 12 people, 19.35%
Stress And Anxiety: 11 people, 17.74%
Fatigue (feeling of tiredness): 11 people, 17.74%
Nausea (feeling of having an urge to vomit): 11 people, 17.74%
Pain: 10 people, 16.13%
Asthma: 10 people, 16.13%
Cough: 9 people, 14.52%

What are the existing conditions these people have? *

Stress And Anxiety: 11 people, 17.74%
Depression: 9 people, 14.52%
High Blood Pressure: 8 people, 12.90%
Asthma: 8 people, 12.90%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 12.90%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 9.68%
Immunodeficiency Common Variable: 6 people, 9.68%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 6 people, 9.68%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 4.84%
Acute Leukaemia (blood cancer): 2 people, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Saphris and have Fever?

- Check whether Fever is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Saphris:

Saphris (8,688 reports)

Fever treatments and more:

Fever (498,666 reports)

Browse all side effects of Saphris:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fever:

Fever (3,494 drugs)

Browse all the conditions that are associated with Fever:

Fever (6,196 conditions)

Related publications that referenced our studies

Schiller D, Maieron A, Sch?fl R, Donnerer J, "Drug fever due to a single dose of pantoprazole", Pharmacology, 2015 Jan .
Schiller D, Maieron A, Sch?fl R, Donnerer J, "Drug fever due to a single dose of pantoprazole", Pharmacology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on asenapine maleate (the active ingredients of Saphris) and Saphris (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.