Savella and Ddd - a phase IV clinical study of FDA data

Summary:

Ddd is reported as a side effect among people who take Savella (milnacipran hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have Neck pain.

The phase IV clinical study analyzes which people have Ddd when taking Savella. It is created by eHealthMe based on reports of 6,561 people who have side effects when taking Savella from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Ddd?

Ddd is found to be associated with 1,370 drugs and 1,405 conditions by eHealthMe. Check the latest studies of Ddd.

On Feb, 12, 2026

6,561 people reported to have side effects when taking Savella.
Among them, 15 people (0.23%) have Ddd.

Among these 15 people:

How long have people been on Savella when they have Ddd? *

What is the gender of people who have Ddd when taking Savella? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Ddd when taking Savella? *

What are other drugs people take besides Savella? *

What are other side effects people have besides Ddd? *

Insomnia (sleeplessness): 8 people, 53.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 46.67%
Stress And Anxiety: 7 people, 46.67%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 6 people, 40.00%
Back Pain: 6 people, 40.00%
Pain In Extremity: 6 people, 40.00%
Joint Pain: 6 people, 40.00%
Neuropathy Peripheral (surface nerve damage): 6 people, 40.00%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 33.33%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 33.33%

What are the existing conditions these people have? *

Neck Pain: 4 people, 26.67%
Polymyalgia Rheumatica (pain in many muscles): 3 people, 20.00%
Sleep Disorder: 3 people, 20.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 20.00%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 20.00%
Post Laminectomy Syndrome: 3 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 13.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 13.33%
High Blood Cholesterol: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Savella and have Ddd?

- Check whether Ddd is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Savella:

Savella (7,529 reports)

Ddd treatments and more:

Ddd (19,908 reports)

Browse all side effects of Savella:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ddd:

Ddd (1,370 drugs)

Browse all the conditions that are associated with Ddd:

Ddd (1,405 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on milnacipran hydrochloride (the active ingredients of Savella) and Savella (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.