Seasonique and Insomnia - a phase IV clinical study of FDA data

Summary:

Insomnia is reported as a side effect among people who take Seasonique (ethinyl estradiol; levonorgestrel), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Insomnia when taking Seasonique. It is created by eHealthMe based on reports of 1,296 people who have side effects when taking Seasonique from the FDA, and is updated regularly.

What is Seasonique?

Seasonique has active ingredients of ethinyl estradiol; levonorgestrel. It is often used in birth control. eHealthMe is studying from 1,718 Seasonique users. Check the latest studies of Seasonique.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,115 drugs and 5,175 conditions by eHealthMe. Check the latest studies of Insomnia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

1,296 people reported to have side effects when taking Seasonique.
Among them, 35 people (2.7%) have Insomnia.

Among these 35 people:

How long have people been on Seasonique when they have Insomnia? *

What is the gender of people who have Insomnia when taking Seasonique? *

female: 100 %
male: 0.0 %

What is the age of people who have Insomnia when taking Seasonique? *

What are other drugs people take besides Seasonique? *

What are other side effects people have besides Insomnia? *

Stress And Anxiety: 18 people, 51.43%
Feeling Hot: 9 people, 25.71%
Weight Decreased: 8 people, 22.86%
Dizziness: 8 people, 22.86%
Therapeutic Response Unexpected: 7 people, 20.00%
Hyperhidrosis (abnormally increased sweating): 7 people, 20.00%
Drowsiness: 6 people, 17.14%
Nasopharyngitis (inflammation of the nasopharynx): 6 people, 17.14%
Abdominal Pain Upper: 6 people, 17.14%
Blood Pressure Fluctuation: 5 people, 14.29%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 20.00%
Nausea (feeling of having an urge to vomit): 6 people, 17.14%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 17.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 14.29%
Migraine (headache): 5 people, 14.29%
Nasal Disorder (diseases of nose): 5 people, 14.29%
Drowsiness: 4 people, 11.43%
Headache (pain in head): 3 people, 8.57%
Stress And Anxiety: 3 people, 8.57%
Panic Disorder: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

Do you take Seasonique and have Insomnia?

- Check whether Insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Seasonique:

Seasonique (1,718 reports)

Insomnia treatments and more:

Insomnia (438,087 reports)

How severe was Insomnia and when was it recovered:

Insomnia in Seasonique

Expand to all the drugs that have ingredients of ethinyl estradiol; levonorgestrel:

Insomnia and drugs with ingredients of ethinyl estradiol; levonorgestrel (426 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Seasonique:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia:

Insomnia (3,115 drugs)

Browse all the conditions that are associated with Insomnia:

Insomnia (5,175 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; levonorgestrel (the active ingredients of Seasonique) and Seasonique (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.