Senna and Localised oedema - a phase IV clinical study of FDA data

Summary:

Localised oedema is reported as a side effect among people who take Senna (senna), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Colace, and have Cardiac amyloidosis.

The phase IV clinical study analyzes which people have Localised oedema when taking Senna. It is created by eHealthMe based on reports of 37,042 people who have side effects when taking Senna from the FDA, and is updated regularly.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

What is Localised oedema?

Localised oedema (fluid retention in a particular part of the body) is found to be associated with 546 drugs and 707 conditions by eHealthMe. Check the latest studies of Localised oedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

37,042 people reported to have side effects when taking Senna.
Among them, 11 people (0.03%) have Localised oedema.

Among these 11 people:

How long have people been on Senna when they have Localised oedema? *

What is the gender of people who have Localised oedema when taking Senna? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Localised oedema when taking Senna? *

What are other drugs people take besides Senna? *

What are other side effects people have besides Localised oedema? *

Oedema Peripheral (superficial swelling): 5 people, 45.45%
Dyspnea (difficult or laboured breathing): 5 people, 45.45%
Weakness: 4 people, 36.36%
Pain: 4 people, 36.36%
Joint Pain: 4 people, 36.36%
Anaemia (lack of blood): 4 people, 36.36%
Electrolyte Imbalance: 3 people, 27.27%
Diarrhea: 3 people, 27.27%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 3 people, 27.27%
Back Pain: 3 people, 27.27%

What are the existing conditions these people have? *

Gastric Cancer (stomach cancer): 2 people, 18.18%
Thrombolysis (resolving the blood clot): 2 people, 18.18%
Acute Kidney Failure: 2 people, 18.18%
Swelling: 2 people, 18.18%
Stress Gastritis (swelling (inflammation) and weakening of the stomach lining that occurs during a serious illness): 2 people, 18.18%
Gout (uric acid crystals building up in the body): 2 people, 18.18%
Anaemia (lack of blood): 2 people, 18.18%
Anorexia Nervosa (psychological disorder-eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 2 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
Cardiac Amyloidosis (protein deposition in heart): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Senna and have Localised oedema?

- Check whether Localised oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Senna:

Senna (37,302 reports)

Browse all side effects of Senna:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Localised oedema:

Localised oedema (546 drugs)

Browse all the conditions that are associated with Localised oedema:

Localised oedema (707 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on senna (the active ingredients of Senna) and Senna (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.