Sennosides and Oedema - a phase IV clinical study of FDA data

Summary:

Oedema is reported as a side effect among people who take Sennosides (senna), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Pain.

The phase IV clinical study analyzes which people have Oedema when taking Sennosides. It is created by eHealthMe based on reports of 8,186 people who have side effects when taking Sennosides from the FDA, and is updated regularly.

What is Sennosides?

Sennosides has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 8,247 Sennosides users. Check the latest studies of Sennosides.

What is Oedema?

Oedema (fluid collection in tissue) is found to be associated with 2,155 drugs and 2,311 conditions by eHealthMe. Check the latest studies of Oedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

8,186 people reported to have side effects when taking Sennosides.
Among them, 47 people (0.57%) have Oedema.

Among these 47 people:

How long have people been on Sennosides when they have Oedema? *

What is the gender of people who have Oedema when taking Sennosides? *

female: 52.38 %
male: 47.62 %

What is the age of people who have Oedema when taking Sennosides? *

What are other drugs people take besides Sennosides? *

What are other side effects people have besides Oedema? *

Fatigue (feeling of tiredness): 16 people, 34.04%
Dyspnea (difficult or laboured breathing): 15 people, 31.91%
Rashes (redness): 14 people, 29.79%
Pain In Extremity: 14 people, 29.79%
Oedema Peripheral (superficial swelling): 13 people, 27.66%
Abdominal Pain: 11 people, 23.40%
Joint Pain: 11 people, 23.40%
Weakness: 10 people, 21.28%
Fever: 10 people, 21.28%
Cellulitis (infection under the skin): 10 people, 21.28%

What are the existing conditions these people have? *

Pain: 7 people, 14.89%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 12.77%
Peripheral Swelling: 5 people, 10.64%
Haemangiopericytoma (soft tissue cancer that originates in the pericytes in the walls of capillaries): 5 people, 10.64%
Insomnia (sleeplessness): 5 people, 10.64%
Abdominal Discomfort: 4 people, 8.51%
Fever: 4 people, 8.51%
High Blood Pressure: 4 people, 8.51%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 3 people, 6.38%
Diabetes: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Sennosides and have Oedema?

- Check whether Oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sennosides:

Sennosides (8,247 reports)

Oedema treatments and more:

Oedema (78,747 reports)

Browse all side effects of Sennosides:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oedema:

Oedema (2,155 drugs)

Browse all the conditions that are associated with Oedema:

Oedema (2,311 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on senna (the active ingredients of Sennosides) and Sennosides (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.