Septocaine and Bone erosion - a phase IV clinical study of FDA data

Summary:

Bone erosion is reported as a side effect among people who take Septocaine (articaine hydrochloride; epinephrine bitartrate), especially for people who are female, 50-59 old, also take Ultram, and have Breast cancer.

The phase IV clinical study analyzes which people have Bone erosion when taking Septocaine. It is created by eHealthMe based on reports of 1,174 people who have side effects when taking Septocaine from the FDA, and is updated regularly.

What is Septocaine?

Septocaine has active ingredients of articaine hydrochloride; epinephrine bitartrate. eHealthMe is studying from 1,182 Septocaine users. Check the latest studies of Septocaine.

What is Bone erosion?

Bone erosion is found to be associated with 494 drugs and 297 conditions by eHealthMe. Check the latest studies of Bone erosion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,174 people reported to have side effects when taking Septocaine.
Among them, 13 people (1.11%) have Bone erosion.

Among these 13 people:

What is the gender of people who have Bone erosion when taking Septocaine? *

female: 100 %
male: 0.0 %

What is the age of people who have Bone erosion when taking Septocaine? *

What are other drugs people take besides Septocaine? *

What are other side effects people have besides Bone erosion? *

Accident: 13 people, 100.00%
Pain: 13 people, 100.00%
Chest Pain: 13 people, 100.00%
Nausea And Vomiting: 13 people, 100.00%
Nausea (feeling of having an urge to vomit): 13 people, 100.00%
Emotional Distress: 13 people, 100.00%
Muscle Aches (muscle pain): 13 people, 100.00%
Mouth Ulcers: 13 people, 100.00%
Migraine (headache): 13 people, 100.00%
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth): 13 people, 100.00%

What are the existing conditions these people have? *

Breast Cancer: 13 people, 100.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 76.92%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 10 people, 76.92%
Neuropathy Peripheral (surface nerve damage): 7 people, 53.85%

* Approximation only. Some reports may have incomplete information.

Do you take Septocaine and have Bone erosion?

- Check whether Bone erosion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Septocaine:

Septocaine (1,182 reports)

Bone erosion treatments and more:

Bone erosion (4,590 reports)

How severe was Bone erosion and when was it recovered:

Bone erosion in Septocaine

Expand to all the drugs that have ingredients of articaine hydrochloride; epinephrine bitartrate:

Bone erosion and drugs with ingredients of articaine hydrochloride; epinephrine bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Septocaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone erosion:

Bone erosion (494 drugs)

Browse all the conditions that are associated with Bone erosion:

Bone erosion (297 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on articaine hydrochloride; epinephrine bitartrate (the active ingredients of Septocaine) and Septocaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.