Septocaine and Depression aggravated - a phase IV clinical study of FDA data

Summary:

Depression aggravated is reported as a side effect among people who take Septocaine (articaine hydrochloride; epinephrine bitartrate), especially for people who are female, 60+ old, also take Arestin, and have Emphysema.

The phase IV clinical study analyzes which people have Depression aggravated when taking Septocaine. It is created by eHealthMe based on reports of 1,174 people who have side effects when taking Septocaine from the FDA, and is updated regularly.

What is Septocaine?

Septocaine has active ingredients of articaine hydrochloride; epinephrine bitartrate. eHealthMe is studying from 1,182 Septocaine users. Check the latest studies of Septocaine.

What is Depression aggravated?

Depression aggravated is found to be associated with 2,363 drugs and 748 conditions by eHealthMe. Check the latest studies of Depression aggravated.

On Jul, 11, 2026

1,174 people reported to have side effects when taking Septocaine.
Among them, 24 people (2.04%) have Depression aggravated.

Could Septocaine cause Depression aggravated?

Among these 24 people:

What is the gender of people who have Depression aggravated when taking Septocaine? *

female: 95.83 %
male: 4.17 %

What is the age of people who have Depression aggravated when taking Septocaine? *

What are other drugs people take besides Septocaine? *

What are other side effects people have besides Depression aggravated? *

Stress And Anxiety: 23 people, 95.83%
Pain: 21 people, 87.50%
Weight Decreased: 18 people, 75.00%
Fatigue (feeling of tiredness): 18 people, 75.00%
Zollinger-Ellison Syndrome (increased production of the hormone gastrin from a small tumour of pancreas): 17 people, 70.83%
Head Injury: 17 people, 70.83%
Osteoporosis (bones weak and more likely to break): 17 people, 70.83%
Osteomyelitis (infection of bone): 17 people, 70.83%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 17 people, 70.83%
Kidney Stones: 17 people, 70.83%

What are the existing conditions these people have? *

Pain: 17 people, 70.83%
High Blood Pressure: 17 people, 70.83%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 17 people, 70.83%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 16.67%
Stress And Anxiety: 2 people, 8.33%
Tooth Disorder (tooth disease): 1 person, 4.17%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Septocaine and have Depression aggravated?

- Check whether Depression aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Septocaine:

Septocaine (1,182 reports)

Depression aggravated treatments and more:

Depression aggravated (2,253 reports)

How severe was Depression aggravated and when was it recovered:

Depression aggravated in Septocaine

Expand to all the drugs that have ingredients of articaine hydrochloride; epinephrine bitartrate:

Depression aggravated and drugs with ingredients of articaine hydrochloride; epinephrine bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Septocaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression aggravated:

Depression aggravated (2,364 drugs)

Browse all the conditions that are associated with Depression aggravated:

Depression aggravated (748 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on articaine hydrochloride; epinephrine bitartrate (the active ingredients of Septocaine) and Septocaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.