Septra ds and Encephalopathy - a phase IV clinical study of FDA data

Summary:

Encephalopathy is reported as a side effect among people who take Septra ds (sulfamethoxazole; trimethoprim), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Paxil, and have High blood pressure.

The phase IV clinical study analyzes which people have Encephalopathy when taking Septra ds. It is created by eHealthMe based on reports of 2,191 people who have side effects when taking Septra ds from the FDA, and is updated regularly.

What is Septra ds?

Septra ds has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 2,349 Septra ds users. Check the latest studies of Septra ds.

What is Encephalopathy?

Encephalopathy (functioning of the brain is affected by some agent or condition) is found to be associated with 1,463 drugs and 1,604 conditions by eHealthMe. Check the latest studies of Encephalopathy.

On Aug, 05, 2026

2,191 people reported to have side effects when taking Septra ds.
Among them, 15 people (0.68%) have Encephalopathy.

Among these 15 people:

How long have people been on Septra ds when they have Encephalopathy? *

What is the gender of people who have Encephalopathy when taking Septra ds? *

female: 28.57 %
male: 71.43 %

What is the age of people who have Encephalopathy when taking Septra ds? *

What are other drugs people take besides Septra ds? *

What are other side effects people have besides Encephalopathy? *

Swallowing Difficulty: 7 people, 46.67%
Cerebral Atrophy (decrement in size of brain): 7 people, 46.67%
Drug Exposure During Pregnancy: 6 people, 40.00%
Unilateral Hydronephrosis (kidney stone that causes obstruction of the ureter): 6 people, 40.00%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 6 people, 40.00%
Immunodeficiency: 6 people, 40.00%
Persistent Foetal Circulation (baby's blood does not need to pass by the lungs): 6 people, 40.00%
Diarrhea: 3 people, 20.00%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 3 people, 20.00%
Hypotension (abnormally low blood pressure): 3 people, 20.00%

What are the existing conditions these people have? *

Vasculitis (inflammation of a blood vessel or blood vessels): 1 person, 6.67%
Stenotrophomonas Infection: 1 person, 6.67%
Renal Disorder (kidney disease): 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Septra ds and have Encephalopathy?

- Check whether Encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Septra ds:

Septra ds (2,349 reports)

Encephalopathy treatments and more:

Encephalopathy (27,832 reports)

How severe was Encephalopathy and when was it recovered:

Encephalopathy in Septra ds

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Encephalopathy and drugs with ingredients of sulfamethoxazole; trimethoprim (852 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Septra ds:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Encephalopathy:

Encephalopathy (1,463 drugs)

Browse all the conditions that are associated with Encephalopathy:

Encephalopathy (1,604 conditions)

Related publications that referenced our studies

Kapoor A, Kumar V, Beniwal S, Dutta S, Goyal S, Kumar HS, "Posterior reversible encephalopathy syndrome in non-Hodgkin's lymphoma: Not necessarily reversible!", Clinical Cancer Investigation Journal, 2015 Mar .
Kapoor A, Kumar V, Beniwal S, Dutta S, Goyal S, Kumar HS, "Posterior reversible encephalopathy syndrome in non-Hodgkin's lymphoma: Not necessarily reversible!", Clinical Cancer Investigation Journal, 2015 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Septra ds) and Septra ds (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.