Serenoa repens and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Serenoa repens (saw palmetto), especially for people who are male, 60+ old, also take Fish Oil, and have Chronic inflammatory demyelinating polyradiculoneuropathy.

The phase IV clinical study analyzes which people have Headache when taking Serenoa repens. It is created by eHealthMe based on reports of 621 people who have side effects when taking Serenoa repens from the FDA, and is updated regularly.

What is Serenoa repens?

Serenoa repens has active ingredients of saw palmetto. eHealthMe is studying from 628 Serenoa repens users. Check the latest studies of Serenoa repens.

What is Headache?

Headache (pain in head) is found to be associated with 3,756 drugs and 5,776 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

621 people reported to have side effects when taking Serenoa repens.
Among them, 18 people (2.9%) have Headache.

Among these 18 people:

What is the gender of people who have Headache when taking Serenoa repens? *

female: 17.65 %
male: 82.35 %

What is the age of people who have Headache when taking Serenoa repens? *

What are other drugs people take besides Serenoa repens? *

What are other side effects people have besides Headache? *

Fatigue (feeling of tiredness): 10 people, 55.56%
Diarrhea: 7 people, 38.89%
Joint Pain: 6 people, 33.33%
Nausea (feeling of having an urge to vomit): 6 people, 33.33%
Neck Pain: 4 people, 22.22%
Itching: 3 people, 16.67%
Gout (uric acid crystals building up in the body): 3 people, 16.67%
Insomnia (sleeplessness): 3 people, 16.67%
Hypoaesthesia (reduced sense of touch or sensation): 3 people, 16.67%
High Blood Pressure: 3 people, 16.67%

What are the existing conditions these people have? *

Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 4 people, 22.22%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 3 people, 16.67%
Immunodeficiency Common Variable: 3 people, 16.67%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 11.11%
High Blood Cholesterol: 2 people, 11.11%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.56%
Enlarged Prostate: 1 person, 5.56%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.56%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Serenoa repens and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Serenoa repens:

Serenoa repens (628 reports)

Headache treatments and more:

Headache (756,645 reports)

Browse all side effects of Serenoa repens:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,756 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,776 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on saw palmetto (the active ingredients of Serenoa repens) and Serenoa repens (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.