Sertraline hydrochloride and Hypernatraemia - a phase IV clinical study of FDA data

Summary:

Hypernatraemia is reported as a side effect among people who take Sertraline hydrochloride (sertraline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Levothyroxine Sodium, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Hypernatraemia when taking Sertraline hydrochloride. It is created by eHealthMe based on reports of 25,997 people who have side effects when taking Sertraline hydrochloride from the FDA, and is updated regularly.

What is Sertraline hydrochloride?

Sertraline hydrochloride has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 28,199 Sertraline hydrochloride users. Check the latest studies of Sertraline hydrochloride.

What is Hypernatraemia?

Hypernatraemia (an abnormally high plasma concentration of sodium ions) is found to be associated with 645 drugs and 807 conditions by eHealthMe. Check the latest studies of Hypernatraemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

25,997 people reported to have side effects when taking Sertraline hydrochloride.
Among them, 25 people (0.1%) have Hypernatraemia.

Could Sertraline hydrochloride cause Hypernatraemia?

Among these 25 people:

How long have people been on Sertraline hydrochloride when they have Hypernatraemia? *

What is the gender of people who have Hypernatraemia when taking Sertraline hydrochloride? *

female: 58.33 %
male: 41.67 %

What is the age of people who have Hypernatraemia when taking Sertraline hydrochloride? *

What are other drugs people take besides Sertraline hydrochloride? *

Simvastatin: 6 people, 24.00%
Zolpidem: 6 people, 24.00%
Aricept: 6 people, 24.00%
Xanax: 6 people, 24.00%
Equanil: 6 people, 24.00%
Levothyroxine Sodium: 6 people, 24.00%
Abilify: 5 people, 20.00%
Acetaminophen: 5 people, 20.00%
Duphalac: 5 people, 20.00%
Memantine Hydrochloride: 5 people, 20.00%

What are other side effects people have besides Hypernatraemia? *

Dehydration (dryness resulting from the removal of water): 9 people, 36.00%
Confusional State: 8 people, 32.00%
Fall: 7 people, 28.00%
Fever: 6 people, 24.00%
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 6 people, 24.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 24.00%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 5 people, 20.00%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 5 people, 20.00%
Hypokalemia (low potassium): 5 people, 20.00%
Confusion: 5 people, 20.00%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 6 people, 24.00%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 4 people, 16.00%
Upper Respiratory Tract Congestion: 1 person, 4.00%
Febrile Neutropenia (fever with reduced white blood cells): 1 person, 4.00%
Breast Cancer: 1 person, 4.00%
Breast Cancer Metastatic: 1 person, 4.00%
Device Occlusion: 1 person, 4.00%
Diabetes: 1 person, 4.00%
Fungal Infection: 1 person, 4.00%
Septic Shock (shock due to blood infection): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline hydrochloride and have Hypernatraemia?

- Check whether Hypernatraemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline hydrochloride:

Sertraline hydrochloride (28,199 reports)

Hypernatraemia treatments and more:

Hypernatraemia (6,339 reports)

Browse all side effects of Sertraline hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypernatraemia:

Hypernatraemia (645 drugs)

Browse all the conditions that are associated with Hypernatraemia:

Hypernatraemia (807 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline hydrochloride) and Sertraline hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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