Sertraline and Joint lock - a phase IV clinical study of FDA data

Summary:

Joint lock is reported as a side effect among people who take Sertraline (sertraline hydrochloride), especially for people who are female, 60+ old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint lock when taking Sertraline. It is created by eHealthMe based on reports of 146,463 people who have side effects when taking Sertraline from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,305 Sertraline users. Check the latest studies of Sertraline.

What is Joint lock?

Joint lock is found to be associated with 299 drugs and 493 conditions by eHealthMe. Check the latest studies of Joint lock.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

146,463 people reported to have side effects when taking Sertraline.
Among them, 31 people (0.02%) have Joint lock.

Among these 31 people:

What is the gender of people who have Joint lock when taking Sertraline? *

female: 74.07 %
male: 25.93 %

What is the age of people who have Joint lock when taking Sertraline? *

What are other drugs people take besides Sertraline? *

Humira: 6 people, 19.35%
Omeprazole: 5 people, 16.13%
Escitalopram: 3 people, 9.68%
Rituxan: 3 people, 9.68%
Vitamin D3: 3 people, 9.68%
Prednisone: 3 people, 9.68%
Zolpidem: 3 people, 9.68%
Cosentyx: 2 people, 6.45%
Bupropion Hydrochloride: 2 people, 6.45%
Simvastatin: 2 people, 6.45%

What are other side effects people have besides Joint lock? *

Joint Pain: 17 people, 54.84%
Back Pain: 16 people, 51.61%
Pain In Extremity: 15 people, 48.39%
Headache (pain in head): 12 people, 38.71%
Fatigue (feeling of tiredness): 12 people, 38.71%
Insomnia (sleeplessness): 11 people, 35.48%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 11 people, 35.48%
Weakness: 10 people, 32.26%
Vision Blurred: 10 people, 32.26%
Dry Eyes (lack of adequate tears): 10 people, 32.26%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 29.03%
Breast Cancer: 8 people, 25.81%
High Blood Pressure: 8 people, 25.81%
High Blood Cholesterol: 7 people, 22.58%
Pain: 4 people, 12.90%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 9.68%
Weight Abnormal: 2 people, 6.45%
Limb Discomfort (discomfort in leg): 2 people, 6.45%
Back Pain: 2 people, 6.45%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline and have Joint lock?

- Check whether Joint lock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline:

Sertraline (153,305 reports)

Joint lock treatments and more:

Joint lock (3,416 reports)

Browse all side effects of Sertraline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint lock:

Joint lock (299 drugs)

Browse all the conditions that are associated with Joint lock:

Joint lock (493 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline) and Sertraline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.