Sertraline and Mean cell volume increased - a phase IV clinical study of FDA data

Summary:

Mean cell volume increased is reported as a side effect among people who take Sertraline (sertraline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Clozaril, and have Schizophrenia.

The phase IV clinical study analyzes which people have Mean cell volume increased when taking Sertraline. It is created by eHealthMe based on reports of 146,463 people who have side effects when taking Sertraline from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,304 Sertraline users. Check the latest studies of Sertraline.

What is Mean cell volume increased?

Mean cell volume increased (more than normal average red blood cell volume) is found to be associated with 455 drugs and 495 conditions by eHealthMe. Check the latest studies of Mean cell volume increased.

On Jul, 17, 2026

146,463 people reported to have side effects when taking Sertraline.
Among them, 59 people (0.04%) have Mean cell volume increased.

Could Sertraline cause Mean cell volume increased?

Among these 59 people:

How long have people been on Sertraline when they have Mean cell volume increased? *

What is the gender of people who have Mean cell volume increased when taking Sertraline? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Mean cell volume increased when taking Sertraline? *

What are other drugs people take besides Sertraline? *

What are other side effects people have besides Mean cell volume increased? *

Red Blood Cell Count Decreased: 46 people, 77.97%
Haematocrit Decreased: 33 people, 55.93%
Haemoglobin Decreased: 32 people, 54.24%
Fever: 26 people, 44.07%
Neutrophil Count Increased (excess than normal number of neutrophil a type of blood cell): 23 people, 38.98%
White Blood Cell Count Increased: 21 people, 35.59%
Dyspnea (difficult or laboured breathing): 19 people, 32.20%
Confusional State: 18 people, 30.51%
Malaise (a feeling of general discomfort or uneasiness): 18 people, 30.51%
Respiratory Rate Increased (excess breathing rate/min): 16 people, 27.12%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 20 people, 33.90%
Psychotic Disorder: 13 people, 22.03%
Type 2 Diabetes: 12 people, 20.34%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 12 people, 20.34%
Ovarian Cancer (cancer of ovary): 5 people, 8.47%
Sleep Disorder: 5 people, 8.47%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.78%
B-Cell Type Acute Leukaemia (cancer of the white blood cells): 4 people, 6.78%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 6.78%
Pain: 4 people, 6.78%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline and have Mean cell volume increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline:

Sertraline (153,304 reports)

Browse all side effects of Sertraline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean cell volume increased:

Mean cell volume increased (455 drugs)

Browse all the conditions that are associated with Mean cell volume increased:

Mean cell volume increased (495 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline) and Sertraline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.