Sertraline and Mitral valve prolapse - a phase IV clinical study of FDA data

Summary:

Mitral valve prolapse is reported as a side effect among people who take Sertraline (sertraline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Fish Oil, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Mitral valve prolapse when taking Sertraline. It is created by eHealthMe based on reports of 146,463 people who have side effects when taking Sertraline from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,305 Sertraline users. Check the latest studies of Sertraline.

What is Mitral valve prolapse?

Mitral valve prolapse (heart's mitral valve doesn't work well) is found to be associated with 504 drugs and 859 conditions by eHealthMe. Check the latest studies of Mitral valve prolapse.

On Aug, 04, 2026

146,463 people reported to have side effects when taking Sertraline.
Among them, 36 people (0.02%) have Mitral valve prolapse.

Could Sertraline cause Mitral valve prolapse?

Among these 36 people:

How long have people been on Sertraline when they have Mitral valve prolapse? *

What is the gender of people who have Mitral valve prolapse when taking Sertraline? *

female: 60 %
male: 40 %

What is the age of people who have Mitral valve prolapse when taking Sertraline? *

What are other drugs people take besides Sertraline? *

What are other side effects people have besides Mitral valve prolapse? *

Dyspnea (difficult or laboured breathing): 19 people, 52.78%
Insomnia (sleeplessness): 18 people, 50.00%
Pain: 17 people, 47.22%
Oedema Peripheral (superficial swelling): 17 people, 47.22%
Tricuspid Valve Incompetence (inefficient heart valve): 17 people, 47.22%
Hypoaesthesia (reduced sense of touch or sensation): 15 people, 41.67%
Mastication Disorder (disease of chewing food): 14 people, 38.89%
Cardiac Failure Congestive: 14 people, 38.89%
Cataract (clouding of the lens inside the eye): 14 people, 38.89%
Hip Fracture: 13 people, 36.11%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 25.00%
Cardiac Disorder: 3 people, 8.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 5.56%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.56%
High Blood Pressure: 2 people, 5.56%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 5.56%
Lactose Intolerance (inability to digest lactose): 2 people, 5.56%
Indigestion: 2 people, 5.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 5.56%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline and have Mitral valve prolapse?

- Check whether Mitral valve prolapse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline:

Sertraline (153,305 reports)

Browse all side effects of Sertraline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mitral valve prolapse:

Mitral valve prolapse (504 drugs)

Browse all the conditions that are associated with Mitral valve prolapse:

Mitral valve prolapse (859 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline) and Sertraline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.