Sertraline and Partial seizures - a phase IV clinical study of FDA data

Summary:

Partial seizures is reported as a side effect among people who take Sertraline (sertraline hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Abilify, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Partial seizures when taking Sertraline. It is created by eHealthMe based on reports of 146,463 people who have side effects when taking Sertraline from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,308 Sertraline users. Check the latest studies of Sertraline.

What is Partial seizures?

Partial seizures (seizures which affect only a part of the brain at onset) is found to be associated with 476 drugs and 726 conditions by eHealthMe. Check the latest studies of Partial seizures.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

146,463 people reported to have side effects when taking Sertraline.
Among them, 84 people (0.06%) have Partial seizures.

Could Sertraline cause Partial seizures?

Among these 84 people:

How long have people been on Sertraline when they have Partial seizures? *

What is the gender of people who have Partial seizures when taking Sertraline? *

female: 47.3 %
male: 52.7 %

What is the age of people who have Partial seizures when taking Sertraline? *

What are other drugs people take besides Sertraline? *

What are other side effects people have besides Partial seizures? *

Drowsiness: 27 people, 32.14%
Dehydration (dryness resulting from the removal of water): 24 people, 28.57%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 23 people, 27.38%
Acidosis (build-up of carbon dioxide in the blood): 23 people, 27.38%
Hypovolaemic Shock (shock caused by severe blood or fluid loss): 23 people, 27.38%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 22 people, 26.19%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 21 people, 25.00%
Gangrene (body tissue dies): 19 people, 22.62%
Hypernatraemia (an abnormally high plasma concentration of sodium ions): 19 people, 22.62%
Weight Decreased: 18 people, 21.43%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 23 people, 27.38%
Encephalitis Autoimmune (autoimmune origin disturbances of consciousness and pyramidal signs, inflammation of the brain): 8 people, 9.52%
Nocardia Infection (a bacterial infection that usually starts in the lungs. it may spread to other organ systems): 7 people, 8.33%
High Blood Pressure: 6 people, 7.14%
Meningoencephalitis Herpetic (inflammation of the brain and meninges by virus): 6 people, 7.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 7.14%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 4.76%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 4 people, 4.76%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 4.76%
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 3 people, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline and have Partial seizures?

- Check whether Partial seizures is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline:

Sertraline (153,308 reports)

Partial seizures treatments and more:

Partial seizures (17,458 reports)

Browse all side effects of Sertraline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Partial seizures:

Partial seizures (476 drugs)

Browse all the conditions that are associated with Partial seizures:

Partial seizures (726 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline) and Sertraline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.