Sertraline and Umbilical hernia - a phase IV clinical study of FDA data

Summary:

Umbilical hernia is reported as a side effect among people who take Sertraline (sertraline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Clonazepam, and have Ulcerative colitis.

The phase IV clinical study analyzes which people have Umbilical hernia when taking Sertraline. It is created by eHealthMe based on reports of 146,463 people who have side effects when taking Sertraline from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,308 Sertraline users. Check the latest studies of Sertraline.

What is Umbilical hernia?

Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button) is found to be associated with 642 drugs and 676 conditions by eHealthMe. Check the latest studies of Umbilical hernia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

146,463 people reported to have side effects when taking Sertraline.
Among them, 59 people (0.04%) have Umbilical hernia.

Could Sertraline cause Umbilical hernia?

Among these 59 people:

How long have people been on Sertraline when they have Umbilical hernia? *

What is the gender of people who have Umbilical hernia when taking Sertraline? *

female: 76.6 %
male: 23.4 %

What is the age of people who have Umbilical hernia when taking Sertraline? *

What are other drugs people take besides Sertraline? *

What are other side effects people have besides Umbilical hernia? *

Fatigue (feeling of tiredness): 22 people, 37.29%
Headache (pain in head): 21 people, 35.59%
Nausea (feeling of having an urge to vomit): 20 people, 33.90%
Dyspnea (difficult or laboured breathing): 16 people, 27.12%
Weight Decreased: 15 people, 25.42%
Abdominal Distension: 15 people, 25.42%
Back Pain: 15 people, 25.42%
Diarrhea: 14 people, 23.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 23.73%
Intervertebral Disc Degeneration (spinal disc degeneration): 13 people, 22.03%

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 16.95%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 10 people, 16.95%
Osteopenia (a condition where bone mineral density is lower than normal): 8 people, 13.56%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 10.17%
High Blood Cholesterol: 5 people, 8.47%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 8.47%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 5 people, 8.47%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 6.78%
Behcet's Syndrome (involves inflammation of the blood vessels): 4 people, 6.78%
Vasculitis (inflammation of a blood vessel or blood vessels): 4 people, 6.78%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline and have Umbilical hernia?

- Check whether Umbilical hernia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline:

Sertraline (153,308 reports)

Browse all side effects of Sertraline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Umbilical hernia:

Umbilical hernia (642 drugs)

Browse all the conditions that are associated with Umbilical hernia:

Umbilical hernia (676 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline) and Sertraline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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