Sildenafil citrate and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Sildenafil citrate (sildenafil citrate), especially for people who are male, 40-49 old, have been taking the drug for 2 - 5 years also take Tecfidera, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Sildenafil citrate. It is created by eHealthMe based on reports of 22,637 people who have side effects when taking Sildenafil citrate from the FDA, and is updated regularly.

What is Sildenafil citrate?

Sildenafil citrate has active ingredients of sildenafil citrate. It is often used in erection problems. eHealthMe is studying from 23,013 Sildenafil citrate users. Check the latest studies of Sildenafil citrate.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,088 drugs and 1,358 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

On May, 07, 2026

22,637 people reported to have side effects when taking Sildenafil citrate.
Among them, 13 people (0.06%) have Multiple sclerosis.

Could Sildenafil citrate cause Multiple sclerosis?

Among these 13 people:

How long have people been on Sildenafil citrate when they have Multiple sclerosis? *

What is the gender of people who have Multiple sclerosis when taking Sildenafil citrate? *

female: 38.46 %
male: 61.54 %

What is the age of people who have Multiple sclerosis when taking Sildenafil citrate? *

What are other drugs people take besides Sildenafil citrate? *

What are other side effects people have besides Multiple sclerosis? *

Fatigue (feeling of tiredness): 4 people, 30.77%
Pain In Extremity: 3 people, 23.08%
Weight Decreased: 3 people, 23.08%
Dyspnea (difficult or laboured breathing): 3 people, 23.08%
Skin Blushing/flushing (a sudden reddening of the face, neck): 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
Oxygen Saturation Decreased: 3 people, 23.08%
Catheter Site Pruritus (itching at the site): 2 people, 15.38%
Hospitalisation: 2 people, 15.38%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 2 people, 15.38%

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 30.77%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 30.77%
Myelopathy (any neurologic deficit related to the spinal cord): 1 person, 7.69%
Dizziness: 1 person, 7.69%
Diplopia (double vision): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Sildenafil citrate and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sildenafil citrate:

Sildenafil citrate (23,013 reports)

Browse all side effects of Sildenafil citrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Multiple sclerosis (1,088 drugs)

Browse all the conditions that are associated with Multiple sclerosis:

Multiple sclerosis (1,358 conditions)

Related publications that referenced our studies

Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sildenafil citrate (the active ingredients of Sildenafil citrate) and Sildenafil citrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.