Silybum and Cystitis aggravated - a phase IV clinical study of FDA data

Summary:

Cystitis aggravated is reported as a side effect among people who take Silybum (milk thistle), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Vitamin D3, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Cystitis aggravated when taking Silybum. It is created by eHealthMe based on reports of 769 people who have side effects when taking Silybum from the FDA, and is updated regularly.

What is Silybum?

Silybum has active ingredients of milk thistle. eHealthMe is studying from 779 Silybum users. Check the latest studies of Silybum.

What is Cystitis aggravated?

Cystitis aggravated (inflammation of the wall of the bladder) is found to be associated with 2,017 drugs and 768 conditions by eHealthMe. Check the latest studies of Cystitis aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

769 people reported to have side effects when taking Silybum.
Among them, 18 people (2.34%) have Cystitis aggravated.

Could Silybum cause Cystitis aggravated?

Among these 18 people:

How long have people been on Silybum when they have Cystitis aggravated? *

What is the gender of people who have Cystitis aggravated when taking Silybum? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Cystitis aggravated when taking Silybum? *

What are other drugs people take besides Silybum? *

What are other side effects people have besides Cystitis aggravated? *

Nausea (feeling of having an urge to vomit): 4 people, 22.22%
Fatigue (feeling of tiredness): 4 people, 22.22%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 22.22%
Weakness: 4 people, 22.22%
Alanine Aminotransferase Increased: 3 people, 16.67%
Dehydration (dryness resulting from the removal of water): 3 people, 16.67%
Fever: 3 people, 16.67%
Dyspnea (difficult or laboured breathing): 3 people, 16.67%
Acute Kidney Failure: 3 people, 16.67%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 3 people, 16.67%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 22.22%
Immunodeficiency Common Variable: 2 people, 11.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.11%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 11.11%
High Blood Pressure: 2 people, 11.11%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 1 person, 5.56%
Asthma: 1 person, 5.56%
Bladder Cancer: 1 person, 5.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 5.56%
Depression: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Silybum and have Cystitis aggravated?

- Check whether Cystitis aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Silybum:

Silybum (779 reports)

Browse all side effects of Silybum:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cystitis aggravated:

Cystitis aggravated (2,017 drugs)

Browse all the conditions that are associated with Cystitis aggravated:

Cystitis aggravated (768 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on milk thistle (the active ingredients of Silybum) and Silybum (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.