Silymarin and Pain - a phase IV clinical study of FDA data

Summary:

Pain is reported as a side effect among people who take Silymarin (milk thistle), especially for people who are female, 60+ old, also take Norco, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Pain when taking Silymarin. It is created by eHealthMe based on reports of 749 people who have side effects when taking Silymarin from the FDA, and is updated regularly.

What is Silymarin?

Silymarin has active ingredients of milk thistle. eHealthMe is studying from 793 Silymarin users. Check the latest studies of Silymarin.

What is Pain?

Pain is found to be associated with 3,817 drugs and 5,864 conditions by eHealthMe. Check the latest studies of Pain.

On Jul, 14, 2026

749 people reported to have side effects when taking Silymarin.
Among them, 24 people (3.2%) have Pain.

Among these 24 people:

What is the gender of people who have Pain when taking Silymarin? *

female: 91.67 %
male: 8.33 %

What is the age of people who have Pain when taking Silymarin? *

What are other drugs people take besides Silymarin? *

What are other side effects people have besides Pain? *

Headache (pain in head): 13 people, 54.17%
Nausea (feeling of having an urge to vomit): 13 people, 54.17%
Gait Disturbance: 11 people, 45.83%
The Flu (the flu is caused by an influenza virus): 11 people, 45.83%
Malaise (a feeling of general discomfort or uneasiness): 9 people, 37.50%
Cartilage Injury: 8 people, 33.33%
Secretion Discharge: 8 people, 33.33%
Diarrhea: 8 people, 33.33%
Fatigue (feeling of tiredness): 8 people, 33.33%
Tooth Injury: 8 people, 33.33%

What are the existing conditions these people have? *

Stress And Anxiety: 8 people, 33.33%
Nausea (feeling of having an urge to vomit): 7 people, 29.17%
High Blood Pressure: 7 people, 29.17%
Hepatitis C: 5 people, 20.83%
Idiopathic Thrombocytopenic Purpura (Itp) (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 4 people, 16.67%
Breast Cancer: 3 people, 12.50%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 12.50%
Liver Disorder (liver diseases): 3 people, 12.50%
Thrombocytopenic Purpura (a bleeding disorder in which the immune system destroys platelets): 3 people, 12.50%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Silymarin and have Pain?

- Check whether Pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Silymarin:

Silymarin (793 reports)

Pain treatments and more:

Pain (1,140,594 reports)

Browse all side effects of Silymarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain:

Pain (3,817 drugs)

Browse all the conditions that are associated with Pain:

Pain (5,864 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on milk thistle (the active ingredients of Silymarin) and Silymarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.