Silymarin and Septic shock - a phase IV clinical study of FDA data

Summary:

Septic shock is reported as a side effect among people who take Silymarin (milk thistle), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Pantoprazole, and have High blood pressure.

The phase IV clinical study analyzes which people have Septic shock when taking Silymarin. It is created by eHealthMe based on reports of 749 people who have side effects when taking Silymarin from the FDA, and is updated regularly.

What is Silymarin?

Silymarin has active ingredients of milk thistle. eHealthMe is studying from 793 Silymarin users. Check the latest studies of Silymarin.

What is Septic shock?

Septic shock (shock due to blood infection) is found to be associated with 1,746 drugs and 3,392 conditions by eHealthMe. Check the latest studies of Septic shock.

On Jul, 07, 2026

749 people reported to have side effects when taking Silymarin.
Among them, 15 people (2.0%) have Septic shock.

Among these 15 people:

How long have people been on Silymarin when they have Septic shock? *

What is the gender of people who have Septic shock when taking Silymarin? *

female: 30.77 %
male: 69.23 %

What is the age of people who have Septic shock when taking Silymarin? *

What are other drugs people take besides Silymarin? *

Pantoprazole: 5 people, 33.33%
Actrapid: 3 people, 20.00%
Amlodipine: 3 people, 20.00%
Cozaar: 3 people, 20.00%
Tasigna: 3 people, 20.00%
Glucophage: 3 people, 20.00%
Glucosamine Hydrochloride: 3 people, 20.00%
Phytomenadione: 3 people, 20.00%
Nph Insulin: 3 people, 20.00%
Levophed: 2 people, 13.33%

What are other side effects people have besides Septic shock? *

Acute Kidney Failure: 4 people, 26.67%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 26.67%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 3 people, 20.00%
Arrhythmias (irregular heartbeat): 3 people, 20.00%
Dyspnea (difficult or laboured breathing): 3 people, 20.00%
Pneumonia: 3 people, 20.00%
Depressed Level Of Consciousness: 2 people, 13.33%
Gangrene (body tissue dies): 2 people, 13.33%
Extremity Necrosis (death of body tissue of arms and legs): 2 people, 13.33%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 2 people, 13.33%

What are the existing conditions these people have? *

Diabetes: 3 people, 20.00%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 20.00%
Respiratory Disorder (respiratory disease): 3 people, 20.00%
Gout (uric acid crystals building up in the body): 3 people, 20.00%
Hepatic Steatosis (fatty liver disease): 3 people, 20.00%
High Blood Pressure: 3 people, 20.00%
Aspergillosis (an infection caused by a fungus called aspergillus): 2 people, 13.33%
Fever: 2 people, 13.33%
Burkitt's Leukaemia (blood cancer): 2 people, 13.33%
Haemoglobin Decreased: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Silymarin and have Septic shock?

- Check whether Septic shock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Silymarin:

Silymarin (793 reports)

Septic shock treatments and more:

Septic shock (51,128 reports)

Browse all side effects of Silymarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Septic shock:

Septic shock (1,746 drugs)

Browse all the conditions that are associated with Septic shock:

Septic shock (3,392 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on milk thistle (the active ingredients of Silymarin) and Silymarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.