Simcor and Arf - a phase IV clinical study of FDA data

Summary:

Arf is reported as a side effect among people who take Simcor (niacin; simvastatin), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Nexium, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Arf when taking Simcor. It is created by eHealthMe based on reports of 11,438 people who have side effects when taking Simcor from the FDA, and is updated regularly.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

What is Arf?

Arf (acute renal failure (arf), is a rapid loss of kidney) is found to be associated with 3,580 drugs and 4,480 conditions by eHealthMe. Check the latest studies of Arf.

On Mar, 26, 2026

11,438 people reported to have side effects when taking Simcor.
Among them, 46 people (0.4%) have Arf.

Among these 46 people:

How long have people been on Simcor when they have Arf? *

What is the gender of people who have Arf when taking Simcor? *

female: 50 %
male: 50 %

What is the age of people who have Arf when taking Simcor? *

What are other drugs people take besides Simcor? *

What are other side effects people have besides Arf? *

Chronic Kidney Disease: 23 people, 50.00%
Renal Injury (kidney injury): 8 people, 17.39%
Skin Blushing/flushing (a sudden reddening of the face, neck): 6 people, 13.04%
Renal Impairment (severely reduced kidney function): 5 people, 10.87%
Pneumonia: 5 people, 10.87%
Suicidal Ideation: 5 people, 10.87%
Cellulitis (infection under the skin): 4 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.70%
Fever: 4 people, 8.70%
Renal Tubular Necrosis (death of kidney tubules): 4 people, 8.70%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 23 people, 50.00%
High Blood Pressure: 22 people, 47.83%
Pain: 14 people, 30.43%
Diabetes: 13 people, 28.26%
Depression: 10 people, 21.74%
Cardiac Disorder: 6 people, 13.04%
Indigestion: 6 people, 13.04%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 10.87%
Thyroid Diseases: 5 people, 10.87%
Asthma: 5 people, 10.87%

* Approximation only. Some reports may have incomplete information.

Do you take Simcor and have Arf?

- Check whether Arf is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simcor:

Simcor (11,604 reports)

Arf treatments and more:

Arf (259,717 reports)

Browse all side effects of Simcor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Arf:

Arf (3,580 drugs)

Browse all the conditions that are associated with Arf:

Arf (4,480 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on niacin; simvastatin (the active ingredients of Simcor) and Simcor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.