Simcor and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Simcor (niacin; simvastatin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Aspirin, and have High density lipoprotein decreased.

The phase IV clinical study analyzes which people have Depression when taking Simcor. It is created by eHealthMe based on reports of 11,438 people who have side effects when taking Simcor from the FDA, and is updated regularly.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

What is Depression?

Depression is found to be associated with 3,220 drugs and 4,063 conditions by eHealthMe. Check the latest studies of Depression.

On Oct, 26, 2025

11,438 people reported to have side effects when taking Simcor.
Among them, 27 people (0.24%) have Depression.

Among these 27 people:

How long have people been on Simcor when they have Depression? *

What is the gender of people who have Depression when taking Simcor? *

female: 28 %
male: 72 %

What is the age of people who have Depression when taking Simcor? *

What are other drugs people take besides Simcor? *

What are other side effects people have besides Depression? *

Skin Blushing/flushing (a sudden reddening of the face, neck): 8 people, 29.63%
Fatigue (feeling of tiredness): 6 people, 22.22%
Back Pain: 6 people, 22.22%
Stress And Anxiety: 6 people, 22.22%
Diarrhea: 6 people, 22.22%
Joint Pain: 5 people, 18.52%
Rashes (redness): 5 people, 18.52%
Itching: 4 people, 14.81%
Weakness: 4 people, 14.81%
Headache (pain in head): 4 people, 14.81%

What are the existing conditions these people have? *

High Density Lipoprotein Decreased: 6 people, 22.22%
High Blood Pressure: 3 people, 11.11%
Acne (skin problems that cause pimples): 2 people, 7.41%
Prostatomegaly (enlargement of the prostate): 2 people, 7.41%
Dyslipidaemia (abnormal amount of lipids): 2 people, 7.41%
Gout (uric acid crystals building up in the body): 2 people, 7.41%
Hiv Infection: 2 people, 7.41%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 3.70%
Acne Cystic (skin problems that cause pimples): 1 person, 3.70%
Bipolar Disorder (mood disorder): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Simcor and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simcor:

Simcor (11,604 reports)

Depression treatments and more:

Depression (652,008 reports)

Browse all side effects of Simcor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,220 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,063 conditions)

Drugs similar to Simcor and Depression :

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on niacin; simvastatin (the active ingredients of Simcor) and Simcor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.