Simponi and Thin bones - a phase IV clinical study of FDA data

Summary:

Thin bones is reported as a side effect among people who take Simponi (golimumab), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Orencia, and have Pain.

The phase IV clinical study analyzes which people have Thin bones when taking Simponi. It is created by eHealthMe based on reports of 86,103 people who have side effects when taking Simponi from the FDA, and is updated regularly.

What is Simponi?

Simponi has active ingredients of golimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 86,327 Simponi users. Check the latest studies of Simponi.

What is Thin bones?

Thin bones is found to be associated with 2,539 drugs and 1,909 conditions by eHealthMe. Check the latest studies of Thin bones.



On Dec, 06, 2025

86,103 people reported to have side effects when taking Simponi.
Among them, 996 people (1.16%) have Thin bones.

Could Simponi cause Thin bones?

Among these 996 people:

How long have people been on Simponi when they have Thin bones? *

  • < 1 month: 12.9 %
  • 1 - 6 months: 19.35 %
  • 6 - 12 months: 41.94 %
  • 1 - 2 years: 6.45 %
  • 2 - 5 years: 19.35 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Thin bones when taking Simponi? *

  • female: 97.24 %
  • male: 2.76 %

What is the age of people who have Thin bones when taking Simponi? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.32 %
  • 20-29: 0.16 %
  • 30-39: 0.0 %
  • 40-49: 11.15 %
  • 50-59: 39.65 %
  • 60+: 48.73 %

What are other drugs people take besides Simponi? *

  1. Orencia: 856 people, 85.94%
  2. Arava: 847 people, 85.04%
  3. Cimzia: 825 people, 82.83%
  4. Enbrel: 806 people, 80.92%
  5. Actemra: 794 people, 79.72%
  6. Xeljanz: 732 people, 73.49%
  7. Humira: 517 people, 51.91%
  8. Otezla: 487 people, 48.90%
  9. Stelara: 438 people, 43.98%
  10. Remicade: 420 people, 42.17%

What are other side effects people have besides Thin bones? *

  1. Drug Ineffective: 820 people, 82.33%
  2. Joint Pain: 526 people, 52.81%
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 500 people, 50.20%
  4. Joint Dislocation (a joint position is changed from normal position): 490 people, 49.20%
  5. Foot Deformity (functional disability of foot): 488 people, 49.00%
  6. Exostosis (formation of new bone on the surface of a bone): 487 people, 48.90%
  7. Bone Erosion: 487 people, 48.90%
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints): 486 people, 48.80%
  9. Joint Stiffness: 478 people, 47.99%
  10. Mobility Decreased (ability to move is reduced): 477 people, 47.89%

What are the existing conditions these people have? *

  1. Pain: 252 people, 25.30%
  2. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 239 people, 24.00%
  3. Psoriasis (immune-mediated disease that affects the skin): 200 people, 20.08%
  4. Joint Pain: 194 people, 19.48%
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints): 148 people, 14.86%
  6. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 106 people, 10.64%
  7. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 45 people, 4.52%
  8. Indigestion: 36 people, 3.61%
  9. Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 30 people, 3.01%
  10. Uveitis (inflammation of the uvea): 25 people, 2.51%

* Approximation only. Some reports may have incomplete information.

Do you take Simponi and have Thin bones?

- Check whether Thin bones is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simponi:

Thin bones treatments and more:

How severe was Thin bones and when was it recovered:

Expand to all the drugs that have ingredients of golimumab:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Simponi side effects:

Browse all side effects of Simponi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Thin bones:

Browse all the drugs that are associated with Thin bones:

Common conditions associated with Thin bones:

Browse all the conditions that are associated with Thin bones:

Drugs similar to Simponi and Thin bones :

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on golimumab (the active ingredients of Simponi) and Simponi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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