Sinemet and Ankle fracture - a phase IV clinical study of FDA data

Summary:

Ankle fracture is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are female, 50-59 old, also take Lasix, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Ankle fracture when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Ankle fracture?

Ankle fracture is found to be associated with 1,115 drugs and 1,050 conditions by eHealthMe. Check the latest studies of Ankle fracture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

28,351 people reported to have side effects when taking Sinemet.
Among them, 32 people (0.11%) have Ankle fracture.

$Could Sinemet cause Ankle fracture?$

Among these 32 people:

What is the gender of people who have Ankle fracture when taking Sinemet? *

female: 77.42 %
male: 22.58 %

What is the age of people who have Ankle fracture when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Ankle fracture? *

Fall: 15 people, 46.88%
Fainting (loss of consciousness and postural tone): 14 people, 43.75%
Dizziness: 11 people, 34.38%
Bradycardia (abnormally slow heart action): 9 people, 28.12%
Loss Of Consciousness: 8 people, 25.00%
Headache (pain in head): 7 people, 21.88%
Arrhythmias (irregular heartbeat): 7 people, 21.88%
Lower Limb Fracture: 7 people, 21.88%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 18.75%
Rashes (redness): 6 people, 18.75%

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 15.62%
Immunodeficiency Common Variable: 5 people, 15.62%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 12.50%
Delusion (a false belief or opinion): 4 people, 12.50%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 12.50%
High Blood Pressure: 3 people, 9.38%
Bipolar Disorder (mood disorder): 3 people, 9.38%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 3 people, 9.38%
Prostate Cancer: 2 people, 6.25%
Pain: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Ankle fracture?

- Check whether Ankle fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,601 reports)

Ankle fracture treatments and more:

Ankle fracture (20,557 reports)

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ankle fracture:

Ankle fracture (1,115 drugs)

Browse all the conditions that are associated with Ankle fracture:

Ankle fracture (1,050 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.