Sinemet and Aplastic anemia - a phase IV clinical study of FDA data

Summary:

Aplastic anemia is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Altace, and have Basedow's disease.

The phase IV clinical study analyzes which people have Aplastic anemia when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Aplastic anemia?

Aplastic anemia is found to be associated with 622 drugs and 886 conditions by eHealthMe. Check the latest studies of Aplastic anemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

28,351 people reported to have side effects when taking Sinemet.
Among them, 16 people (0.06%) have Aplastic anemia.

Among these 16 people:

How long have people been on Sinemet when they have Aplastic anemia? *

What is the gender of people who have Aplastic anemia when taking Sinemet? *

female: 50 %
male: 50 %

What is the age of people who have Aplastic anemia when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Aplastic anemia? *

Impaired Healing: 8 people, 50.00%
Therapeutic Response Decreased (less preventive response): 8 people, 50.00%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 8 people, 50.00%
Carnitine Decreased: 7 people, 43.75%
Thrombocytopenia (decrease of platelets in blood): 6 people, 37.50%
Fever: 5 people, 31.25%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 25.00%
Breath Sounds Decreased: 4 people, 25.00%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 4 people, 25.00%
Cough: 4 people, 25.00%

What are the existing conditions these people have? *

Diabetes: 2 people, 12.50%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 2 people, 12.50%
Hyperthyroidism (over activity of the thyroid gland): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%
Asthma: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Aplastic anemia?

- Check whether Aplastic anemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,601 reports)

Aplastic anemia treatments and more:

Aplastic anemia (14,870 reports)

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aplastic anemia:

Aplastic anemia (622 drugs)

Browse all the conditions that are associated with Aplastic anemia:

Aplastic anemia (886 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.