Sinemet and Cachexia - a phase IV clinical study of FDA data

Summary:

Cachexia is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are male, 60+ old, also take Prevacid, and have Constipation.

The phase IV clinical study analyzes which people have Cachexia when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,600 Sinemet users. Check the latest studies of Sinemet.

What is Cachexia?

Cachexia (loss of weight) is found to be associated with 671 drugs and 1,200 conditions by eHealthMe. Check the latest studies of Cachexia.

On Mar, 17, 2026

28,351 people reported to have side effects when taking Sinemet.
Among them, 20 people (0.07%) have Cachexia.

Among these 20 people:

What is the gender of people who have Cachexia when taking Sinemet? *

female: 30 %
male: 70 %

What is the age of people who have Cachexia when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Cachexia? *

Pneumonia: 7 people, 35.00%
Speech Impairment (Adult) (inability to speak (adult)): 5 people, 25.00%
Tracheomalacia (a structural abnormality of the tracheal (windpipe) cartilage resulting in the collapse of the wall of the trachea which obstructs the airway): 5 people, 25.00%
Apnea (temporary absence or cessation of breathing): 5 people, 25.00%
Weakness: 4 people, 20.00%
Thrombocytopenia (decrease of platelets in blood): 4 people, 20.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 15.00%
Confusional State: 3 people, 15.00%
Swallowing Difficulty: 3 people, 15.00%
Drug Ineffective: 3 people, 15.00%

What are the existing conditions these people have? *

Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 5 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 25.00%
Constipation: 5 people, 25.00%
Rashes (redness): 2 people, 10.00%
Pain: 2 people, 10.00%
High Blood Cholesterol: 2 people, 10.00%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 10.00%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 10.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.00%
Psychomotor Hyperactivity (feelings of extreme restlessness): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Cachexia?

- Check whether Cachexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,600 reports)

Cachexia treatments and more:

Cachexia (7,763 reports)

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cachexia:

Cachexia (671 drugs)

Browse all the conditions that are associated with Cachexia:

Cachexia (1,200 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.