Sinemet and Gingival bleeding - a phase IV clinical study of FDA data

Summary:

Gingival bleeding is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are female, 60+ old, also take Zometa, and have Osteoporosis.

The phase IV clinical study analyzes which people have Gingival bleeding when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Gingival bleeding?

Gingival bleeding (bleeding gums) is found to be associated with 1,027 drugs and 1,082 conditions by eHealthMe. Check the latest studies of Gingival bleeding.

On Jul, 21, 2026

28,351 people reported to have side effects when taking Sinemet.
Among them, 33 people (0.12%) have Gingival bleeding.

Among these 33 people:

What is the gender of people who have Gingival bleeding when taking Sinemet? *

female: 78.79 %
male: 21.21 %

What is the age of people who have Gingival bleeding when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Gingival bleeding? *

Pain: 23 people, 69.70%
Osteoporosis (bones weak and more likely to break): 21 people, 63.64%
Diarrhea: 18 people, 54.55%
Hypokalemia (low potassium): 18 people, 54.55%
Mitral Valve Incompetence (inefficient heart valve): 18 people, 54.55%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 18 people, 54.55%
Loose Tooth: 17 people, 51.52%
Pleural Effusion (water on the lungs): 17 people, 51.52%
Sinus Bradycardia (an unusually slow heartbeat due to heart disease): 17 people, 51.52%
Pain In Extremity: 17 people, 51.52%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 16 people, 48.48%
Breast Cancer: 15 people, 45.45%
Metastases To Bone (cancer spreads to bone): 15 people, 45.45%
Osteopenia (a condition where bone mineral density is lower than normal): 15 people, 45.45%
Belching (release of gas from the digestive tract): 4 people, 12.12%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 9.09%
High Blood Pressure: 3 people, 9.09%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.06%
Back Pain: 2 people, 6.06%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Gingival bleeding?

- Check whether Gingival bleeding is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,601 reports)

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gingival bleeding:

Gingival bleeding (1,027 drugs)

Browse all the conditions that are associated with Gingival bleeding:

Gingival bleeding (1,082 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.