Sinemet and Hyperthyroidism - a phase IV clinical study of FDA data

Summary:

Hyperthyroidism is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are female, 60+ old, also take Clonazepam, and have Drowsiness.

The phase IV clinical study analyzes which people have Hyperthyroidism when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,600 Sinemet users. Check the latest studies of Sinemet.

What is Hyperthyroidism?

Hyperthyroidism (over activity of the thyroid gland) is found to be associated with 1,048 drugs and 1,416 conditions by eHealthMe. Check the latest studies of Hyperthyroidism.

On Aug, 26, 2025

28,351 people reported to have side effects when taking Sinemet.
Among them, 18 people (0.06%) have Hyperthyroidism.

Among these 18 people:

What is the gender of people who have Hyperthyroidism when taking Sinemet? *

female: 88.89 %
male: 11.11 %

What is the age of people who have Hyperthyroidism when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Hyperthyroidism? *

Dyskinesia (abnormality or impairment of voluntary movement): 11 people, 61.11%
Weight Fluctuation: 10 people, 55.56%
Constipation: 10 people, 55.56%
Fibroma (tumours that are composed of fibrous or connective tissue): 8 people, 44.44%
Nervousness: 8 people, 44.44%
Dyschezia (difficulty in defecating): 8 people, 44.44%
Drug Ineffective: 8 people, 44.44%
On And Off Phenomenon: 8 people, 44.44%
Stress And Anxiety: 8 people, 44.44%
Pulmonary Embolism (blockage of the main artery of the lung): 8 people, 44.44%

What are the existing conditions these people have? *

Drowsiness: 5 people, 27.78%
Belching (release of gas from the digestive tract): 4 people, 22.22%
Type 2 Diabetes: 2 people, 11.11%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.56%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%
Gastritis (inflammation of stomach): 1 person, 5.56%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 5.56%
Dyslipidaemia (abnormal amount of lipids): 1 person, 5.56%
Dementia (madness): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Hyperthyroidism?

- Check whether Hyperthyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,600 reports)

Hyperthyroidism treatments and more:

Hyperthyroidism (26,827 reports)

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperthyroidism:

Hyperthyroidism (1,048 drugs)

Browse all the conditions that are associated with Hyperthyroidism:

Hyperthyroidism (1,416 conditions)

Drugs similar to Sinemet and Hyperthyroidism :

Related publications that referenced our studies

Dulani S, Dulani R, Lele S, Diagavane S, Anjankar S, Jaiswal N, Subramaniam PS, Juneja R, "Chronic Subdural Haematoma in a Case of Hyperthyroidism Presenting with Papilledema", Chinese Medicine, 2012 Dec .
Dulani S, Dulani R, Lele S, Diagavane S, Anjankar S, Jaiswal N, Subramaniam PS, Juneja R, "Chronic Subdural Haematoma in a Case of Hyperthyroidism Presenting with Papilledema", Chinese Medicine, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.