Sinemet and Tardive dyskinesia - a phase IV clinical study of FDA data

Summary:

Tardive dyskinesia is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Metoclopramide, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Tardive dyskinesia when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Tardive dyskinesia?

Tardive dyskinesia (a disorder that involves involuntary movements) is found to be associated with 760 drugs and 1,323 conditions by eHealthMe. Check the latest studies of Tardive dyskinesia.

On Jul, 26, 2026

28,351 people reported to have side effects when taking Sinemet.
Among them, 80 people (0.28%) have Tardive dyskinesia.

Among these 80 people:

How long have people been on Sinemet when they have Tardive dyskinesia? *

What is the gender of people who have Tardive dyskinesia when taking Sinemet? *

female: 72 %
male: 28 %

What is the age of people who have Tardive dyskinesia when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Tardive dyskinesia? *

Tremor (trembling or shaking movements in one or more parts of your body): 27 people, 33.75%
Dyskinesia (abnormality or impairment of voluntary movement): 26 people, 32.50%
Emotional Disorder: 25 people, 31.25%
Stress And Anxiety: 25 people, 31.25%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 22 people, 27.50%
Back Pain: 20 people, 25.00%
Depression: 20 people, 25.00%
Joint Pain: 18 people, 22.50%
Nausea (feeling of having an urge to vomit): 17 people, 21.25%
Constipation: 17 people, 21.25%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 17.50%
Impaired Gastric Emptying: 7 people, 8.75%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 4 people, 5.00%
Belching (release of gas from the digestive tract): 4 people, 5.00%
Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 3.75%
Sleep Disorder: 3 people, 3.75%
Nausea (feeling of having an urge to vomit): 3 people, 3.75%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 2.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 2.50%
Akathisia (a movement disorder characterized by a feeling of inner restlessness): 2 people, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Tardive dyskinesia?

- Check whether Tardive dyskinesia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,601 reports)

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tardive dyskinesia:

Tardive dyskinesia (760 drugs)

Browse all the conditions that are associated with Tardive dyskinesia:

Tardive dyskinesia (1,323 conditions)

Related publications that referenced our studies

Manjunatha N, Ganjekar S, Mahendra JV, Kilara N, Srinivasa R, "Tardive Dyskinesia Associated With Anastrozole", The Journal of neuropsychiatry and clinical neurosciences, 2013 Jan .
Manjunatha N, Ganjekar S, Mahendra JV, Kilara N, Srinivasa R, "Tardive Dyskinesia Associated With Anastrozole", The Journal of neuropsychiatry and clinical neurosciences, 2013 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.