Sinemet and Vitamin b12 deficiency - a phase IV clinical study of FDA data

Summary:

Vitamin b12 deficiency is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are female, 60+ old, also take Rivastigmine, and have Cognitive disorder.

The phase IV clinical study analyzes which people have Vitamin b12 deficiency when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Vitamin b12 deficiency?

Vitamin b12 deficiency is found to be associated with 633 drugs and 740 conditions by eHealthMe. Check the latest studies of Vitamin b12 deficiency.

On Jul, 13, 2026

28,351 people reported to have side effects when taking Sinemet.
Among them, 14 people (0.05%) have Vitamin b12 deficiency.

Could Sinemet cause Vitamin b12 deficiency?

Among these 14 people:

What is the gender of people who have Vitamin b12 deficiency when taking Sinemet? *

female: 64.29 %
male: 35.71 %

What is the age of people who have Vitamin b12 deficiency when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Vitamin b12 deficiency? *

Memory Loss: 8 people, 57.14%
Mobility Decreased (ability to move is reduced): 8 people, 57.14%
Fatigue (feeling of tiredness): 8 people, 57.14%
Visual Impairment: 7 people, 50.00%
Nightmares (unpleasant dreams): 7 people, 50.00%
Urinary Tract Infection: 7 people, 50.00%
Dyskinesia (abnormality or impairment of voluntary movement): 6 people, 42.86%
Neuropathy Peripheral (surface nerve damage): 6 people, 42.86%
On And Off Phenomenon: 6 people, 42.86%
Muscle Rigidity (muscle stiffness): 6 people, 42.86%

What are the existing conditions these people have? *

Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 5 people, 35.71%
Bowel Movement Irregularity: 4 people, 28.57%
Abnormal Faeces (abnormal stool): 4 people, 28.57%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 21.43%
Stress And Anxiety: 1 person, 7.14%
Sleep Disorder: 1 person, 7.14%
Pain: 1 person, 7.14%
Muscle Spasms (muscle contraction): 1 person, 7.14%
Metabolic Disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 1 person, 7.14%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Vitamin b12 deficiency?

- Check whether Vitamin b12 deficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,601 reports)

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vitamin b12 deficiency:

Vitamin b12 deficiency (633 drugs)

Browse all the conditions that are associated with Vitamin b12 deficiency:

Vitamin b12 deficiency (740 conditions)

Related publications that referenced our studies

Rajsekhar P, Reddy MM, Vaddera S, Rajini G, Tikeli V, "A Rare Case of Vitamin B12 Deficiency with Ascites", Journal of clinical and diagnostic research: JCDR, 2014 Jan .
Rajsekhar P, Reddy MM, Vaddera S, Rajini G, Tikeli V, "A Rare Case of Vitamin B12 Deficiency with Ascites", Journal of clinical and diagnostic research: JCDR, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.