Sirolimus and Clostridium difficile colitis - a phase IV clinical study of FDA data

Summary:

Clostridium difficile colitis is reported as a side effect among people who take Sirolimus (sirolimus), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Tacrolimus, and have Pancytopenia.

The phase IV clinical study analyzes which people have Clostridium difficile colitis when taking Sirolimus. It is created by eHealthMe based on reports of 11,812 people who have side effects when taking Sirolimus from the FDA, and is updated regularly.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

What is Clostridium difficile colitis?

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection) is found to be associated with 1,042 drugs and 1,782 conditions by eHealthMe. Check the latest studies of Clostridium difficile colitis.

On Jul, 19, 2026

11,812 people reported to have side effects when taking Sirolimus.
Among them, 44 people (0.37%) have Clostridium difficile colitis.

Could Sirolimus cause Clostridium difficile colitis?

Among these 44 people:

How long have people been on Sirolimus when they have Clostridium difficile colitis? *

What is the gender of people who have Clostridium difficile colitis when taking Sirolimus? *

female: 15 %
male: 85 %

What is the age of people who have Clostridium difficile colitis when taking Sirolimus? *

What are other drugs people take besides Sirolimus? *

Tacrolimus: 15 people, 34.09%
Mycophenolate Mofetil: 13 people, 29.55%
Acyclovir: 9 people, 20.45%
Valcyte: 9 people, 20.45%
Bactrim: 9 people, 20.45%
Pepcid: 8 people, 18.18%
Atarax: 7 people, 15.91%
Prevacid: 7 people, 15.91%
Protonix: 7 people, 15.91%
Ultram: 7 people, 15.91%

What are other side effects people have besides Clostridium difficile colitis? *

Sepsis (a severe blood infection that can lead to organ failure and death): 11 people, 25.00%
Fever: 9 people, 20.45%
Ascites (accumulation of fluid in the abdominal cavity): 9 people, 20.45%
Hepatic Enzyme Increased: 9 people, 20.45%
Cholangitis (infection of the bile duct): 9 people, 20.45%
Pleural Effusion (water on the lungs): 9 people, 20.45%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 8 people, 18.18%
Histology Abnormal: 8 people, 18.18%
Gastrointestinal Perforation (hole in the digestive tract): 8 people, 18.18%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 8 people, 18.18%

What are the existing conditions these people have? *

Hepatomegaly (abnormal enlargement of the liver): 8 people, 18.18%
Ascites (accumulation of fluid in the abdominal cavity): 8 people, 18.18%
Pleural Effusion (water on the lungs): 8 people, 18.18%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 8 people, 18.18%
Immunodeficiency Disorders: 4 people, 9.09%
Bone Marrow Conditioning Regimen: 4 people, 9.09%
Oral Candidiasis (fungal infection of mouth): 3 people, 6.82%
Chronic Granulomatous Disease (immune system cells are unable to kill some types of bacteria and fungi): 3 people, 6.82%
High Blood Pressure: 2 people, 4.55%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Sirolimus and have Clostridium difficile colitis?

- Check whether Clostridium difficile colitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sirolimus:

Sirolimus (11,823 reports)

Browse all side effects of Sirolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Clostridium difficile colitis:

Clostridium difficile colitis (1,042 drugs)

Browse all the conditions that are associated with Clostridium difficile colitis:

Clostridium difficile colitis (1,782 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sirolimus (the active ingredients of Sirolimus) and Sirolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.