Sirolimus and Secondary immunodeficiency - a phase IV clinical study of FDA data

Summary:

Secondary immunodeficiency is reported as a side effect among people who take Sirolimus (sirolimus), especially for people who are 60+ old, also take Prednisolone, and have Henoch-schonlein purpura.

The phase IV clinical study analyzes which people have Secondary immunodeficiency when taking Sirolimus. It is created by eHealthMe based on reports of 11,812 people who have side effects when taking Sirolimus from the FDA, and is updated regularly.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

What is Secondary immunodeficiency?

Secondary immunodeficiency (lack of immunity due to some disease) is found to be associated with 136 drugs and 161 conditions by eHealthMe. Check the latest studies of Secondary immunodeficiency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

11,812 people reported to have side effects when taking Sirolimus.
Among them, 15 people (0.13%) have Secondary immunodeficiency.

Could Sirolimus cause Secondary immunodeficiency?

Among these 15 people:

What is the age of people who have Secondary immunodeficiency when taking Sirolimus? *

What are other drugs people take besides Sirolimus? *

Prednisolone: 7 people, 46.67%
Mycophenolate Mofetil: 4 people, 26.67%
Methylprednisolone: 4 people, 26.67%
Azathioprine: 4 people, 26.67%
Myfortic: 3 people, 20.00%
Methylprednisolone Sodium Succinate: 3 people, 20.00%

What are other side effects people have besides Secondary immunodeficiency? *

Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 7 people, 46.67%
Fever: 4 people, 26.67%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 26.67%
Neuropathy Peripheral (surface nerve damage): 3 people, 20.00%
Escherichia Urinary Tract Infection (urinary tract infection by escherichia coli): 3 people, 20.00%
Hypoaesthesia (reduced sense of touch or sensation): 3 people, 20.00%
Weight Decreased: 3 people, 20.00%
Joint Pain: 3 people, 20.00%
Diarrhea: 3 people, 20.00%
Chronic Allograft Nephropathy (failure of kidney transplant): 3 people, 20.00%

What are the existing conditions these people have? *

Polyomavirus Test Positive: 3 people, 20.00%
Henoch-Schonlein Purpura (inflammation of the blood vessels in the skin and other body organs): 3 people, 20.00%
Vasculitis Gastrointestinal (inflammation of the blood vessel wall involving the gastrointestinal): 1 person, 6.67%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 1 person, 6.67%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 6.67%
Pulmonary Vasculitis: 1 person, 6.67%
Immunodeficiency Disorders: 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Gastrointestinal Mucosal Disorder (disorder of gastrointestinal lining mucous membranes): 1 person, 6.67%
Blood Pressure Abnormal: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Sirolimus and have Secondary immunodeficiency?

- Check whether Secondary immunodeficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sirolimus:

Sirolimus (11,823 reports)

Browse all side effects of Sirolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Secondary immunodeficiency:

Secondary immunodeficiency (136 drugs)

Browse all the conditions that are associated with Secondary immunodeficiency:

Secondary immunodeficiency (161 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sirolimus (the active ingredients of Sirolimus) and Sirolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.