Skyclarys and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Skyclarys (omaveloxolone), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Finasteride, and have Friedreich's ataxia.

The phase IV clinical study analyzes which people have Headache when taking Skyclarys. It is created by eHealthMe based on reports of 369 people who have side effects when taking Skyclarys from the FDA, and is updated regularly.

What is Skyclarys?

Skyclarys has active ingredients of omaveloxolone. eHealthMe is studying from 369 Skyclarys users. Check the latest studies of Skyclarys.

What is Headache?

Headache (pain in head) is found to be associated with 3,754 drugs and 5,775 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

369 people reported to have side effects when taking Skyclarys.
Among them, 31 people (8.4%) have Headache.

Among these 31 people:

How long have people been on Skyclarys when they have Headache? *

What is the gender of people who have Headache when taking Skyclarys? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Headache when taking Skyclarys? *

What are other drugs people take besides Skyclarys? *

What are other side effects people have besides Headache? *

Fatigue (feeling of tiredness): 10 people, 32.26%
Muscle Aches (muscle pain): 8 people, 25.81%
Nausea (feeling of having an urge to vomit): 8 people, 25.81%
Hepatic Enzyme Increased: 6 people, 19.35%
Stress And Anxiety: 5 people, 16.13%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 12.90%
Dizziness: 4 people, 12.90%
Pain: 4 people, 12.90%
Nausea And Vomiting: 4 people, 12.90%
Alanine Aminotransferase Increased: 3 people, 9.68%

What are the existing conditions these people have? *

Friedreich's Ataxia (damage to the nervous system): 29 people, 93.55%
Heart Rate Decreased: 2 people, 6.45%
Hair Loss: 2 people, 6.45%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 3.23%
Stress And Anxiety: 1 person, 3.23%
Osteoporosis (bones weak and more likely to break): 1 person, 3.23%
Muscle Spasms (muscle contraction): 1 person, 3.23%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 1 person, 3.23%
High Blood Pressure: 1 person, 3.23%
High Blood Cholesterol: 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Skyclarys and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Skyclarys:

Skyclarys (369 reports)

Headache treatments and more:

Headache (756,642 reports)

Browse all side effects of Skyclarys:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,755 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,775 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on omaveloxolone (the active ingredients of Skyclarys) and Skyclarys (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.