1. Home
  2. Analysis
  3. Skyla
  4. Pimples

Skyla and Pimples - a phase IV clinical study of FDA data

Summary:

Pimples is reported as a side effect among people who take Skyla (levonorgestrel), especially for people who are female, 20-29 old, have been taking the drug for 6 - 12 months also take Kyleena, and have Cataplexy.

The phase IV clinical study analyzes which people have Pimples when taking Skyla. It is created by eHealthMe based on reports of 5,413 people who have side effects when taking Skyla from the FDA, and is updated regularly.

What is Skyla?

Skyla has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 5,452 Skyla users. Check the latest studies of Skyla.

What is Pimples?

Pimples is found to be associated with 2,337 drugs and 2,355 conditions by eHealthMe. Check the latest studies of Pimples.

On Jul, 15, 2026

5,413 people reported to have side effects when taking Skyla.
Among them, 47 people (0.87%) have Pimples.

Could Skyla cause Pimples?

Among these 47 people:

How long have people been on Skyla when they have Pimples? *

  • < 1 month: 15.38 %
  • 1 - 6 months: 15.38 %
  • 6 - 12 months: 30.77 %
  • 1 - 2 years: 7.69 %
  • 2 - 5 years: 23.08 %
  • 5 - 10 years: 7.69 %
  • 10+ years: 0.0 %

What is the gender of people who have Pimples when taking Skyla? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Pimples when taking Skyla? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 11.76 %
  • 20-29: 52.94 %
  • 30-39: 29.41 %
  • 40-49: 5.88 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Skyla? *

  1. Kyleena: 2 people, 4.26%
  2. Zoloft: 1 person, 2.13%
  3. Yasmin: 1 person, 2.13%
  4. Xyrem: 1 person, 2.13%
  5. Provigil: 1 person, 2.13%
  6. Probiotics: 1 person, 2.13%
  7. Mirena: 1 person, 2.13%
  8. Hydroxyzine Pamoate: 1 person, 2.13%
  9. Crestor: 1 person, 2.13%

What are other side effects people have besides Pimples? *

  1. Weight Increased: 8 people, 17.02%
  2. Genital Haemorrhage (bleeding from genital): 6 people, 12.77%
  3. Pain: 5 people, 10.64%
  4. Abdominal Pain Lower: 5 people, 10.64%
  5. Abdominal Distension: 5 people, 10.64%
  6. Depression: 4 people, 8.51%
  7. Hair Loss: 4 people, 8.51%
  8. Rashes (redness): 4 people, 8.51%
  9. Nausea (feeling of having an urge to vomit): 4 people, 8.51%
  10. Chest Pain: 3 people, 6.38%

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 2.13%
  2. Heavy Or Prolong Menstrual Bleeding: 1 person, 2.13%
  3. Dysmenorrhea (painful menstruation): 1 person, 2.13%
  4. Drowsiness: 1 person, 2.13%
  5. Depression: 1 person, 2.13%
  6. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Skyla and have Pimples?

- Check whether Pimples is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Skyla:

Pimples treatments and more:

How severe was Pimples and when was it recovered:

Expand to all the drugs that have ingredients of levonorgestrel:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Skyla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pimples:

Browse all the conditions that are associated with Pimples:

How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel (the active ingredients of Skyla) and Skyla (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.