Skyla and Sleep issues - a phase IV clinical study of FDA data

Summary:

Sleep issues is reported as a side effect among people who take Skyla (levonorgestrel), especially for people who are female, 20-29 old, also take Vitamin D, and have Abdominal pain lower.

The phase IV clinical study analyzes which people have Sleep issues when taking Skyla. It is created by eHealthMe based on reports of 5,413 people who have side effects when taking Skyla from the FDA, and is updated regularly.

What is Skyla?

Skyla has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 5,452 Skyla users. Check the latest studies of Skyla.

What is Sleep issues?

Sleep issues (sleep problems) is found to be associated with 4,222 drugs and 5,359 conditions by eHealthMe. Check the latest studies of Sleep issues.

On Jul, 22, 2026

5,413 people reported to have side effects when taking Skyla.
Among them, 12 people (0.22%) have Sleep issues.

Among these 12 people:

What is the gender of people who have Sleep issues when taking Skyla? *

female: 100 %
male: 0.0 %

What is the age of people who have Sleep issues when taking Skyla? *

What are other drugs people take besides Skyla? *

What are other side effects people have besides Sleep issues? *

Stress And Anxiety: 4 people, 33.33%
Abdominal Distension: 2 people, 16.67%
Acne (skin problems that cause pimples): 2 people, 16.67%
Feeling Abnormal: 2 people, 16.67%
Mood Swings (an extreme or rapid change in mood): 2 people, 16.67%
Muscle Spasms (muscle contraction): 2 people, 16.67%
Chest Pain: 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Sexual Intercourse - Painful: 2 people, 16.67%
Vaginal Bleeding: 2 people, 16.67%

What are the existing conditions these people have? *

Urinary Tract Infection: 1 person, 8.33%
Genital Haemorrhage (bleeding from genital): 1 person, 8.33%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 1 person, 8.33%
Anaemia (lack of blood): 1 person, 8.33%
Acne (skin problems that cause pimples): 1 person, 8.33%
Abdominal Pain Lower: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Skyla and have Sleep issues?

- Check whether Sleep issues is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Skyla:

Skyla (5,452 reports)

Sleep issues treatments and more:

Sleep issues (438,079 reports)

Browse all side effects of Skyla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sleep issues:

Sleep issues (4,222 drugs)

Browse all the conditions that are associated with Sleep issues:

Sleep issues (5,359 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel (the active ingredients of Skyla) and Skyla (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.