Sodium bicarbonate and Hyperammonaemia - a phase IV clinical study of FDA data

Summary:

Hyperammonaemia is reported as a side effect among people who take Sodium bicarbonate (sodium bicarbonate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Chlorpheniramine Maleate, and have Infection.

The phase IV clinical study analyzes which people have Hyperammonaemia when taking Sodium bicarbonate. It is created by eHealthMe based on reports of 27,114 people who have side effects when taking Sodium bicarbonate from the FDA, and is updated regularly.

What is Sodium bicarbonate?

Sodium bicarbonate has active ingredients of sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 27,283 Sodium bicarbonate users. Check the latest studies of Sodium bicarbonate.

What is Hyperammonaemia?

Hyperammonaemia is found to be associated with 397 drugs and 562 conditions by eHealthMe. Check the latest studies of Hyperammonaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

27,114 people reported to have side effects when taking Sodium bicarbonate.
Among them, 20 people (0.07%) have Hyperammonaemia.

Could Sodium bicarbonate cause Hyperammonaemia?

Among these 20 people:

How long have people been on Sodium bicarbonate when they have Hyperammonaemia? *

What is the gender of people who have Hyperammonaemia when taking Sodium bicarbonate? *

female: 52.63 %
male: 47.37 %

What is the age of people who have Hyperammonaemia when taking Sodium bicarbonate? *

What are other drugs people take besides Sodium bicarbonate? *

Chlorpheniramine Maleate: 6 people, 30.00%
Furosemide: 5 people, 25.00%
Ursodiol: 5 people, 25.00%
Sodium Chloride: 5 people, 25.00%
Amlodipine: 4 people, 20.00%
Methylprednisolone: 4 people, 20.00%
Granisetron Hydrochloride: 4 people, 20.00%
Zopiclone: 3 people, 15.00%
Micafungin Sodium: 3 people, 15.00%
Fludarabine Phosphate: 3 people, 15.00%

What are other side effects people have besides Hyperammonaemia? *

Hypotension (abnormally low blood pressure): 6 people, 30.00%
Encephalopathy (functioning of the brain is affected by some agent or condition): 4 people, 20.00%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 4 people, 20.00%
Drug Ineffective: 3 people, 15.00%
Depressed Level Of Consciousness: 3 people, 15.00%
Lactic Acidosis (low ph in body tissues): 3 people, 15.00%
Breathing - Slowed Or Stopped: 3 people, 15.00%
Hypernatraemia (an abnormally high plasma concentration of sodium ions): 3 people, 15.00%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 3 people, 15.00%
Hyperthyroidism (over activity of the thyroid gland): 3 people, 15.00%

What are the existing conditions these people have? *

Hypotension (abnormally low blood pressure): 5 people, 25.00%
High Blood Pressure: 5 people, 25.00%
Infection: 5 people, 25.00%
Hepatocellular Carcinoma (liver cancer): 4 people, 20.00%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 3 people, 15.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 15.00%
Bone Marrow Conditioning Regimen: 3 people, 15.00%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 3 people, 15.00%
Delirium (wild excitement): 3 people, 15.00%
Insomnia (sleeplessness): 3 people, 15.00%

* Approximation only. Some reports may have incomplete information.

Do you take Sodium bicarbonate and have Hyperammonaemia?

- Check whether Hyperammonaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sodium bicarbonate:

Sodium bicarbonate (27,283 reports)

Hyperammonaemia treatments and more:

Hyperammonaemia (6,053 reports)

Browse all side effects of Sodium bicarbonate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperammonaemia:

Hyperammonaemia (397 drugs)

Browse all the conditions that are associated with Hyperammonaemia:

Hyperammonaemia (562 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sodium bicarbonate (the active ingredients of Sodium bicarbonate) and Sodium bicarbonate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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