Sodium bicarbonate and Rebound effect - a phase IV clinical study of FDA data

Summary:

Rebound effect is reported as a side effect among people who take Sodium bicarbonate (sodium bicarbonate), especially for people who are male, 40-49 old, also take Taltz, and have Lupus nephritis.

The phase IV clinical study analyzes which people have Rebound effect when taking Sodium bicarbonate. It is created by eHealthMe based on reports of 27,114 people who have side effects when taking Sodium bicarbonate from the FDA, and is updated regularly.

What is Sodium bicarbonate?

Sodium bicarbonate has active ingredients of sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 27,283 Sodium bicarbonate users. Check the latest studies of Sodium bicarbonate.

What is Rebound effect?

Rebound effect (take-back effect) is found to be associated with 368 drugs and 569 conditions by eHealthMe. Check the latest studies of Rebound effect.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

27,114 people reported to have side effects when taking Sodium bicarbonate.
Among them, 14 people (0.05%) have Rebound effect.

Could Sodium bicarbonate cause Rebound effect?

Among these 14 people:

What is the gender of people who have Rebound effect when taking Sodium bicarbonate? *

female: 41.67 %
male: 58.33 %

What is the age of people who have Rebound effect when taking Sodium bicarbonate? *

What are other drugs people take besides Sodium bicarbonate? *

What are other side effects people have besides Rebound effect? *

Renal Impairment (severely reduced kidney function): 7 people, 50.00%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 6 people, 42.86%
High Blood Pressure: 6 people, 42.86%
Diarrhea: 6 people, 42.86%
High Blood Cholesterol: 6 people, 42.86%
Herpes Zoster: 6 people, 42.86%
Crystalluria (crystals found in the urine): 3 people, 21.43%
Drug Ineffective: 3 people, 21.43%
Hyperkalemia (damage to or disease of the kidney): 2 people, 14.29%
Drug Level Increased: 2 people, 14.29%

What are the existing conditions these people have? *

Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 6 people, 42.86%
Oedema (fluid collection in tissue): 5 people, 35.71%
Osteosarcoma (a cancerous (malignant) bone tumour): 3 people, 21.43%
Fluid Overload (too much fluid in the blood): 3 people, 21.43%
Venous Occlusion (the blocking of venous return): 1 person, 7.14%
Urination - Painful: 1 person, 7.14%
Renal Salt-Wasting Syndrome (lack of sodium due to excess excretion in urine): 1 person, 7.14%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 7.14%
Ill-Defined Disorder: 1 person, 7.14%
High Blood Pressure: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Sodium bicarbonate and have Rebound effect?

- Check whether Rebound effect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sodium bicarbonate:

Sodium bicarbonate (27,283 reports)

Rebound effect treatments and more:

Rebound effect (8,859 reports)

Browse all side effects of Sodium bicarbonate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rebound effect:

Rebound effect (368 drugs)

Browse all the conditions that are associated with Rebound effect:

Rebound effect (569 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sodium bicarbonate (the active ingredients of Sodium bicarbonate) and Sodium bicarbonate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.