Soliris and Granulopenia - a phase IV clinical study of FDA data

Summary:

Granulopenia is reported as a side effect among people who take Soliris (eculizumab), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Bactrim, and have Paroxysmal nocturnal haemoglobinuria.

The phase IV clinical study analyzes which people have Granulopenia when taking Soliris. It is created by eHealthMe based on reports of 58,774 people who have side effects when taking Soliris from the FDA, and is updated regularly.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

What is Granulopenia?

Granulopenia (low white blood cell count) is found to be associated with 3,120 drugs and 3,546 conditions by eHealthMe. Check the latest studies of Granulopenia.

On Nov, 25, 2025

58,774 people reported to have side effects when taking Soliris.
Among them, 450 people (0.77%) have Granulopenia.

Among these 450 people:

How long have people been on Soliris when they have Granulopenia? *

What is the gender of people who have Granulopenia when taking Soliris? *

female: 56.83 %
male: 43.17 %

What is the age of people who have Granulopenia when taking Soliris? *

What are other drugs people take besides Soliris? *

What are other side effects people have besides Granulopenia? *

Fever: 73 people, 16.22%
Thrombocytopenia (decrease of platelets in blood): 65 people, 14.44%
Fatigue (feeling of tiredness): 48 people, 10.67%
Haemoglobin Decreased: 45 people, 10.00%
Leukopenia (less number of white blood cells in blood): 44 people, 9.78%
Anaemia (lack of blood): 42 people, 9.33%
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid): 42 people, 9.33%
Headache (pain in head): 38 people, 8.44%
Blood Lactate Dehydrogenase Increased: 33 people, 7.33%
Pneumonia: 30 people, 6.67%

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 232 people, 51.56%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 67 people, 14.89%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 24 people, 5.33%
Meningoencephalitis Herpetic (inflammation of the brain and meninges by virus): 24 people, 5.33%
Brain Abscess: 24 people, 5.33%
High Blood Pressure: 20 people, 4.44%
Iron Overload: 12 people, 2.67%
Pain: 10 people, 2.22%
Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 10 people, 2.22%
Pulmonary Embolism (blockage of the main artery of the lung): 10 people, 2.22%

* Approximation only. Some reports may have incomplete information.

Do you take Soliris and have Granulopenia?

- Check whether Granulopenia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Soliris:

Soliris (58,821 reports)

Granulopenia treatments and more:

Granulopenia (213,266 reports)

Common Soliris side effects:

Browse all side effects of Soliris:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Granulopenia:

Browse all the drugs that are associated with Granulopenia:

Granulopenia (3,120 drugs)

Common conditions associated with Granulopenia:

Multiple myeloma: 11,962 reports
Breast cancer: 6,926 reports
Carcinoma - ductal: 6,849 reports
Breast cancer metastatic: 6,846 reports
Hypertension: 5,984 reports
High blood pressure: 5,945 reports
Schizophrenia: 5,900 reports
Non-hodgkin's lymphoma: 4,423 reports
Diffuse large b-cell lymphoma: 4,399 reports
Cancer - non-hodgkin's lymphoma: 4,398 reports

Browse all the conditions that are associated with Granulopenia:

Granulopenia (3,546 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on eculizumab (the active ingredients of Soliris) and Soliris (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.