Soliris and Joint dislocation - a phase IV clinical study of FDA data


Joint dislocation is found among people who take Soliris, especially for people who are female, 50-59 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Soliris and have Joint dislocation. It is created by eHealthMe based on reports of 53,818 people who have side effects when taking Soliris from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 18, 2022

53,818 people reported to have side effects when taking Soliris.
Among them, 22 people (0.04%) have Joint dislocation.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 51,642 Soliris users for its effectiveness, alternative drugs and more.

What is Joint dislocation?

Joint dislocation (a joint position is changed from normal position) is found to be associated with 1,314 drugs and 838 conditions by eHealthMe.

Number of Soliris and Joint dislocation reports submitted per year:

Could Soliris cause Joint dislocation?

Time on Soliris when people have Joint dislocation *:

  • < 1 month: 75 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 25 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Joint dislocation when taking Soliris *:

  • female: 70.59 %
  • male: 29.41 %

Age of people who have Joint dislocation when taking Soliris *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 28.57 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 57.14 %
  • 60+: 14.29 %

Common drugs people take besides Soliris *:

  1. Tylenol: 4 people, 18.18%
  2. Calcium: 4 people, 18.18%
  3. Celebrex: 4 people, 18.18%
  4. Colace: 4 people, 18.18%
  5. Coumadin: 4 people, 18.18%
  6. Nasonex: 4 people, 18.18%
  7. Fragmin: 4 people, 18.18%
  8. Amoxicillin And Clavulanate Potassium: 3 people, 13.64%
  9. Lactobacillus Rhamnosus: 2 people, 9.09%
  10. Aranesp: 1 person, 4.55%

Common side effects people have besides Joint dislocation *:

  1. Fall: 10 people, 45.45%
  2. Fever: 6 people, 27.27%
  3. Cough: 5 people, 22.73%
  4. Head Injury: 5 people, 22.73%
  5. Headache (pain in head): 5 people, 22.73%
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 18.18%
  7. Pain In Extremity: 4 people, 18.18%
  8. Pelvic Pain: 4 people, 18.18%
  9. Nosebleed (bleeding from nose): 4 people, 18.18%
  10. Epicondylitis (tennis elbow): 4 people, 18.18%

Common conditions people have *:

  1. Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 11 people, 50.00%
  2. International Normalised Ratio Decreased: 4 people, 18.18%
  3. Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 4 people, 18.18%
  4. Pain: 2 people, 9.09%
  5. Headache (pain in head): 2 people, 9.09%
  6. Transplant Rejection (a transplant material is not worked): 1 person, 4.55%
  7. Diarrhea: 1 person, 4.55%
  8. Dry Skin: 1 person, 4.55%
  9. Fever: 1 person, 4.55%
  10. Flatulence (flatus expelled through the anus): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Soliris and have Joint dislocation?

Check whether Joint dislocation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Joint dislocation and when was it recovered:

Expand to all the drugs that have ingredients of eculizumab:

Alternative drugs to, pros and cons of Soliris:

Common Soliris side effects:

Browse all side effects of Soliris:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Joint dislocation treatments and more:

COVID vaccines that are related to Joint dislocation:

Common drugs associated with Joint dislocation:

All the drugs that are associated with Joint dislocation:

Common conditions associated with Joint dislocation:

All the conditions that are associated with Joint dislocation:

How the study uses the data?

The study uses data from the FDA. It is based on eculizumab (the active ingredients of Soliris) and Soliris (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: