Solu-cortef and Small intestinal perforation - a phase IV clinical study of FDA data

Summary:

Small intestinal perforation is reported as a side effect among people who take Solu-cortef (hydrocortisone sodium succinate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Cellcept, and have Alcoholic liver disease.

The phase IV clinical study analyzes which people have Small intestinal perforation when taking Solu-cortef. It is created by eHealthMe based on reports of 7,966 people who have side effects when taking Solu-cortef from the FDA, and is updated regularly.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

What is Small intestinal perforation?

Small intestinal perforation (hole in small intestine) is found to be associated with 232 drugs and 424 conditions by eHealthMe. Check the latest studies of Small intestinal perforation.

On Aug, 04, 2026

7,966 people reported to have side effects when taking Solu-cortef.
Among them, 12 people (0.15%) have Small intestinal perforation.

Could Solu-cortef cause Small intestinal perforation?

Among these 12 people:

How long have people been on Solu-cortef when they have Small intestinal perforation? *

What is the gender of people who have Small intestinal perforation when taking Solu-cortef? *

female: 50 %
male: 50 %

What is the age of people who have Small intestinal perforation when taking Solu-cortef? *

What are other drugs people take besides Solu-cortef? *

What are other side effects people have besides Small intestinal perforation? *

Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 7 people, 58.33%
Infusion Related Reaction: 6 people, 50.00%
Gangrene (body tissue dies): 4 people, 33.33%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 4 people, 33.33%
Drug Ineffective: 4 people, 33.33%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 4 people, 33.33%
Hypoxic-Ischaemic Encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total): 4 people, 33.33%
Abdominal Sepsis (abdominal infection): 4 people, 33.33%
Postoperative Wound Infection: 4 people, 33.33%
Klebsiella Infection: 4 people, 33.33%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 33.33%
Alcoholic Liver Disease: 4 people, 33.33%
Stomatitis (inflammation of mucous membrane of mouth): 2 people, 16.67%
Rashes (redness): 2 people, 16.67%
Insomnia (sleeplessness): 2 people, 16.67%
Infusion Related Reaction: 2 people, 16.67%
Fever: 2 people, 16.67%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 16.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 16.67%
Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Solu-cortef and have Small intestinal perforation?

- Check whether Small intestinal perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Solu-cortef:

Solu-cortef (7,983 reports)

Small intestinal perforation treatments and more:

Small intestinal perforation (2,178 reports)

How severe was Small intestinal perforation and when was it recovered:

Small intestinal perforation in Solu-cortef

Expand to all the drugs that have ingredients of hydrocortisone sodium succinate:

Small intestinal perforation and drugs with ingredients of hydrocortisone sodium succinate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Solu-cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Small intestinal perforation:

Small intestinal perforation (232 drugs)

Browse all the conditions that are associated with Small intestinal perforation:

Small intestinal perforation (424 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone sodium succinate (the active ingredients of Solu-cortef) and Solu-cortef (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.