Spiriva and Gingival bleeding - a phase IV clinical study of FDA data

Summary:

Gingival bleeding is reported as a side effect among people who take Spiriva (tiotropium bromide monohydrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aredia, and have High blood pressure.

The phase IV clinical study analyzes which people have Gingival bleeding when taking Spiriva. It is created by eHealthMe based on reports of 155,418 people who have side effects when taking Spiriva from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Gingival bleeding?

Gingival bleeding (bleeding gums) is found to be associated with 1,027 drugs and 1,082 conditions by eHealthMe. Check the latest studies of Gingival bleeding.

On Jul, 19, 2026

155,418 people reported to have side effects when taking Spiriva.
Among them, 89 people (0.06%) have Gingival bleeding.

Among these 89 people:

How long have people been on Spiriva when they have Gingival bleeding? *

What is the gender of people who have Gingival bleeding when taking Spiriva? *

female: 85.19 %
male: 14.81 %

What is the age of people who have Gingival bleeding when taking Spiriva? *

What are other drugs people take besides Spiriva? *

What are other side effects people have besides Gingival bleeding? *

Dyspnea (difficult or laboured breathing): 35 people, 39.33%
Osteonecrosis Of Jaw (death of bone of jaw): 34 people, 38.20%
Joint Pain: 31 people, 34.83%
Pain: 31 people, 34.83%
Hypoaesthesia (reduced sense of touch or sensation): 28 people, 31.46%
Vision Blurred: 27 people, 30.34%
Cataract (clouding of the lens inside the eye): 24 people, 26.97%
Constipation: 24 people, 26.97%
Tricuspid Valve Incompetence (inefficient heart valve): 23 people, 25.84%
Nosebleed (bleeding from nose): 22 people, 24.72%

What are the existing conditions these people have? *

High Blood Pressure: 15 people, 16.85%
Breast Cancer: 12 people, 13.48%
Metastases To Bone (cancer spreads to bone): 10 people, 11.24%
Depression: 10 people, 11.24%
Multiple Myeloma (cancer of the plasma cells): 9 people, 10.11%
Breast Cancer Metastatic: 9 people, 10.11%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 7.87%
Muscle Spasms (muscle contraction): 6 people, 6.74%
Osteoporosis (bones weak and more likely to break): 6 people, 6.74%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 5.62%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and have Gingival bleeding?

- Check whether Gingival bleeding is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spiriva:

Spiriva (156,666 reports)

Gingival bleeding treatments and more:

Gingival bleeding (16,715 reports)

How severe was Gingival bleeding and when was it recovered:

Gingival bleeding in Spiriva

Expand to all the drugs that have ingredients of tiotropium bromide monohydrate:

Gingival bleeding and drugs with ingredients of tiotropium bromide monohydrate (74 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gingival bleeding:

Gingival bleeding (1,027 drugs)

Browse all the conditions that are associated with Gingival bleeding:

Gingival bleeding (1,082 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate (the active ingredients of Spiriva) and Spiriva (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.