Spiriva and Grand mal convulsion - a phase IV clinical study of FDA data

Summary:

Grand mal convulsion is reported as a side effect among people who take Spiriva (tiotropium bromide monohydrate), especially for people who are female, 60+ old, also take Dilantin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Grand mal convulsion when taking Spiriva. It is created by eHealthMe based on reports of 155,418 people who have side effects when taking Spiriva from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Grand mal convulsion?

Grand mal convulsion (a type of generalized seizure that affects the entire brain) is found to be associated with 923 drugs and 1,337 conditions by eHealthMe. Check the latest studies of Grand mal convulsion.

On Jul, 12, 2026

155,418 people reported to have side effects when taking Spiriva.
Among them, 36 people (0.02%) have Grand mal convulsion.

Could Spiriva cause Grand mal convulsion?

Among these 36 people:

What is the gender of people who have Grand mal convulsion when taking Spiriva? *

female: 88.89 %
male: 11.11 %

What is the age of people who have Grand mal convulsion when taking Spiriva? *

What are other drugs people take besides Spiriva? *

What are other side effects people have besides Grand mal convulsion? *

Fall: 12 people, 33.33%
Urination - Painful: 9 people, 25.00%
Acute Kidney Failure: 9 people, 25.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 9 people, 25.00%
High Blood Pressure: 8 people, 22.22%
Depression: 8 people, 22.22%
Pelvic Pain: 7 people, 19.44%
Femur Fracture: 7 people, 19.44%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 7 people, 19.44%
Nephrosclerosis (hardening of the kidney due to renovascular disease): 7 people, 19.44%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 8 people, 22.22%
Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 19.44%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 13.89%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 11.11%
Depression: 3 people, 8.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 5.56%
High Blood Cholesterol: 2 people, 5.56%
Pancreatic Carcinoma (pancreatic cancer): 2 people, 5.56%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 5.56%
Birth Control: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and have Grand mal convulsion?

- Check whether Grand mal convulsion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spiriva:

Spiriva (156,666 reports)

Grand mal convulsion treatments and more:

Grand mal convulsion (19,182 reports)

How severe was Grand mal convulsion and when was it recovered:

Grand mal convulsion in Spiriva

Expand to all the drugs that have ingredients of tiotropium bromide monohydrate:

Grand mal convulsion and drugs with ingredients of tiotropium bromide monohydrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Grand mal convulsion:

Grand mal convulsion (923 drugs)

Browse all the conditions that are associated with Grand mal convulsion:

Grand mal convulsion (1,337 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate (the active ingredients of Spiriva) and Spiriva (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.