Spiriva and Hypocoagulable state - a phase IV clinical study of FDA data

Summary:

Hypocoagulable state is reported as a side effect among people who take Spiriva (tiotropium bromide monohydrate), especially for people who are male, 60+ old, also take Coumadin, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Hypocoagulable state when taking Spiriva. It is created by eHealthMe based on reports of 155,418 people who have side effects when taking Spiriva from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Hypocoagulable state?

Hypocoagulable state (abnormality of blood coagulation that increases the risk of thrombosis) is found to be associated with 138 drugs and 289 conditions by eHealthMe. Check the latest studies of Hypocoagulable state.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

155,418 people reported to have side effects when taking Spiriva.
Among them, 15 people (0.01%) have Hypocoagulable state.

Could Spiriva cause Hypocoagulable state?

Among these 15 people:

What is the gender of people who have Hypocoagulable state when taking Spiriva? *

female: 28.57 %
male: 71.43 %

What is the age of people who have Hypocoagulable state when taking Spiriva? *

What are other drugs people take besides Spiriva? *

What are other side effects people have besides Hypocoagulable state? *

Nosebleed (bleeding from nose): 3 people, 20.00%
International Normalised Ratio Increased: 2 people, 13.33%
Hypoglycaemic Coma (coma due to deficiency of glucose in the bloodstream): 2 people, 13.33%
Coughing Up Blood: 2 people, 13.33%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 6.67%
Prothrombin Time Ratio Increased: 1 person, 6.67%
Peritoneal Haemorrhage (peritoneal bleeding): 1 person, 6.67%
Overdose: 1 person, 6.67%
Malaise (a feeling of general discomfort or uneasiness): 1 person, 6.67%
Death: 1 person, 6.67%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 40.00%
Congestive Cardiomyopathy (weakening of heart muscle): 4 people, 26.67%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 3 people, 20.00%
Productive Cough: 3 people, 20.00%
Type 1 Diabetes: 2 people, 13.33%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 6.67%
Ischaemic Stroke (stroke; caused by an interruption in the flow of blood to the brain): 1 person, 6.67%
Ischaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease): 1 person, 6.67%
Respiratory Tract Infection: 1 person, 6.67%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and have Hypocoagulable state?

- Check whether Hypocoagulable state is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spiriva:

Spiriva (156,666 reports)

Hypocoagulable state treatments and more:

Hypocoagulable state (1,106 reports)

How severe was Hypocoagulable state and when was it recovered:

Hypocoagulable state in Spiriva

Expand to all the drugs that have ingredients of tiotropium bromide monohydrate:

Hypocoagulable state and drugs with ingredients of tiotropium bromide monohydrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypocoagulable state:

Hypocoagulable state (138 drugs)

Browse all the conditions that are associated with Hypocoagulable state:

Hypocoagulable state (289 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate (the active ingredients of Spiriva) and Spiriva (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.