Spravato and Crying - a phase IV clinical study of FDA data

Summary:

Crying is reported as a side effect among people who take Spravato (esketamine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Vyvanse, and have Depression.

The phase IV clinical study analyzes which people have Crying when taking Spravato. It is created by eHealthMe based on reports of 7,912 people who have side effects when taking Spravato from the FDA, and is updated regularly.

What is Spravato?

Spravato has active ingredients of esketamine hydrochloride. eHealthMe is studying from 7,920 Spravato users. Check the latest studies of Spravato.

What is Crying?

Crying is found to be associated with 1,406 drugs and 1,803 conditions by eHealthMe. Check the latest studies of Crying.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

7,912 people reported to have side effects when taking Spravato.
Among them, 66 people (0.83%) have Crying.

Among these 66 people:

How long have people been on Spravato when they have Crying? *

What is the gender of people who have Crying when taking Spravato? *

female: 80.7 %
male: 19.3 %

What is the age of people who have Crying when taking Spravato? *

What are other drugs people take besides Spravato? *

What are other side effects people have besides Crying? *

Dissociation: 22 people, 33.33%
Stress And Anxiety: 15 people, 22.73%
Suicidal Ideation: 14 people, 21.21%
Sedation: 9 people, 13.64%
Depression: 9 people, 13.64%
Feeling Abnormal: 8 people, 12.12%
Panic Disorder: 7 people, 10.61%
Euphoric Mood (excessively happy but may become angry or irritable): 6 people, 9.09%
Emotional Disorder: 6 people, 9.09%
High Blood Pressure: 5 people, 7.58%

What are the existing conditions these people have? *

Depression: 44 people, 66.67%
Negative Thoughts: 1 person, 1.52%
Nasopharyngitis (inflammation of the nasopharynx): 1 person, 1.52%
Multiple Allergies (allergy to multiple agents): 1 person, 1.52%

* Approximation only. Some reports may have incomplete information.

Do you take Spravato and have Crying?

- Check whether Crying is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spravato:

Spravato (7,920 reports)

Crying treatments and more:

Crying (43,771 reports)

Browse all side effects of Spravato:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Crying:

Crying (1,407 drugs)

Browse all the conditions that are associated with Crying:

Crying (1,803 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on esketamine hydrochloride (the active ingredients of Spravato) and Spravato (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.