Stelazine and Pruritus aggravated - a phase IV clinical study of FDA data

Summary:

Pruritus aggravated is reported as a side effect among people who take Stelazine (trifluoperazine hydrochloride), especially for people who are female, 60+ old, also take Zoloft, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Pruritus aggravated when taking Stelazine. It is created by eHealthMe based on reports of 1,259 people who have side effects when taking Stelazine from the FDA, and is updated regularly.

What is Stelazine?

Stelazine has active ingredients of trifluoperazine hydrochloride. It is often used in schizophrenia. eHealthMe is studying from 1,311 Stelazine users. Check the latest studies of Stelazine.

What is Pruritus aggravated?

Pruritus aggravated (serious severe itching of the skin) is found to be associated with 2,483 drugs and 1,071 conditions by eHealthMe. Check the latest studies of Pruritus aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,259 people reported to have side effects when taking Stelazine.
Among them, 21 people (1.67%) have Pruritus aggravated.

Could Stelazine cause Pruritus aggravated?

Among these 21 people:

What is the gender of people who have Pruritus aggravated when taking Stelazine? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Pruritus aggravated when taking Stelazine? *

What are other drugs people take besides Stelazine? *

What are other side effects people have besides Pruritus aggravated? *

Hair Loss: 7 people, 33.33%
Weight Decreased: 6 people, 28.57%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 6 people, 28.57%
Vulvovaginal Candidiasis (vulvovaginal infection by fungi): 5 people, 23.81%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 19.05%
Nasopharyngitis (inflammation of the nasopharynx): 4 people, 19.05%
Rashes (redness): 3 people, 14.29%
Depression: 3 people, 14.29%
Diabetes: 3 people, 14.29%
Eye Disorder: 3 people, 14.29%

What are the existing conditions these people have? *

Affective Disorder (mental disorder): 2 people, 9.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 9.52%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 4.76%
Depression: 1 person, 4.76%
Akathisia (a movement disorder characterized by a feeling of inner restlessness): 1 person, 4.76%
Asthma: 1 person, 4.76%
Bipolar Disorder (mood disorder): 1 person, 4.76%
Compression Fracture (fracture due to pressure caused by injury): 1 person, 4.76%
Constipation: 1 person, 4.76%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Stelazine and have Pruritus aggravated?

- Check whether Pruritus aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Stelazine:

Stelazine (1,311 reports)

Browse all side effects of Stelazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pruritus aggravated:

Pruritus aggravated (2,483 drugs)

Browse all the conditions that are associated with Pruritus aggravated:

Pruritus aggravated (1,071 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on trifluoperazine hydrochloride (the active ingredients of Stelazine) and Stelazine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.