Subutex and Abdominal distension - a phase IV clinical study of FDA data


Abdominal distension is found among people who take Subutex, especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Subutex and have Abdominal distension. It is created by eHealthMe based on reports of 7,842 people who have side effects when taking Subutex from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

7,842 people reported to have side effects when taking Subutex.
Among them, 17 people (0.22%) have Abdominal distension.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,273 Subutex users for its effectiveness, alternative drugs and more.

What is Abdominal distension?

Abdominal distension is found to be associated with 3,823 drugs and 2,924 conditions by eHealthMe.

Number of Subutex and Abdominal distension reports submitted per year:

Could Subutex cause Abdominal distension?

Time on Subutex when people have Abdominal distension *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 75 %
  • 6 - 12 months: 25 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Abdominal distension when taking Subutex *:

  • female: 75 %
  • male: 25 %

Age of people who have Abdominal distension when taking Subutex *:

  • 0-1: 12.5 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 12.5 %
  • 40-49: 12.5 %
  • 50-59: 37.5 %
  • 60+: 25.0 %

Common drugs people take besides Subutex *:

  1. Xanax: 6 people, 35.29%
  2. Suboxone: 6 people, 35.29%
  3. Celexa: 4 people, 23.53%
  4. Atarax: 3 people, 17.65%
  5. Cymbalta: 2 people, 11.76%
  6. Sertraline: 2 people, 11.76%
  7. Remicade: 2 people, 11.76%
  8. Oxycodone: 2 people, 11.76%
  9. Ativan: 2 people, 11.76%
  10. Librium: 2 people, 11.76%

Common side effects people have besides Abdominal distension *:

  1. Tremor Neonatal (excited neuromuscular activity of newborns): 6 people, 35.29%
  2. Sneezing: 5 people, 29.41%
  3. Drug Withdrawal Syndrome Neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother): 5 people, 29.41%
  4. Bradycardia Foetal (abnormally slow fetal heart rate, usually below 100 beats/min): 5 people, 29.41%
  5. Apgar Score Low: 5 people, 29.41%
  6. Abdominal Pain: 4 people, 23.53%
  7. Headache (pain in head): 4 people, 23.53%
  8. Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 23.53%
  9. Weight Decreased: 3 people, 17.65%
  10. Hypotonia Neonatal (low muscle tone in neonatal): 3 people, 17.65%

Common conditions people have *:

  1. Depression: 3 people, 17.65%
  2. Panic Disorder: 2 people, 11.76%
  3. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.88%
  4. Stress And Anxiety: 1 person, 5.88%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
  6. Nausea (feeling of having an urge to vomit): 1 person, 5.88%
  7. High Blood Pressure: 1 person, 5.88%
  8. Drug Dependence: 1 person, 5.88%
  9. Constipation: 1 person, 5.88%
  10. Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Subutex and have Abdominal distension?

Check whether Abdominal distension is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Abdominal distension and when was it recovered:

Expand to all the drugs that have ingredients of buprenorphine hydrochloride:

Alternative drugs to, pros and cons of Subutex:

Common Subutex side effects:

Browse all side effects of Subutex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Abdominal distension treatments and more:

COVID vaccines that are related to Abdominal distension:

Common drugs associated with Abdominal distension:

All the drugs that are associated with Abdominal distension:

Common conditions associated with Abdominal distension:

All the conditions that are associated with Abdominal distension:

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride (the active ingredients of Subutex) and Subutex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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