Sudafed and Hot flush - a phase IV clinical study of FDA data


Hot flush is found among people who take Sudafed, especially for people who are 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Sudafed and have Hot flush. It is created by eHealthMe based on reports of 10,737 people who have side effects when taking Sudafed from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 15, 2023

10,737 people reported to have side effects when taking Sudafed.
Among them, 79 people (0.74%) have Hot flush.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,467 Sudafed users for its effectiveness, alternative drugs and more.

What is Hot flush?

Hot flush (sudden feelings of heat) is found to be associated with 3,107 drugs and 2,294 conditions by eHealthMe.

Number of Sudafed and Hot flush reports submitted per year:

Could Sudafed cause Hot flush?

Time on Sudafed when people have Hot flush *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Age of people who have Hot flush when taking Sudafed *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.61 %
  • 20-29: 9.68 %
  • 30-39: 16.13 %
  • 40-49: 8.06 %
  • 50-59: 29.03 %
  • 60+: 35.48 %

Common drugs people take besides Sudafed *:

  1. Calcium: 14 people, 17.72%
  2. Norvasc: 13 people, 16.46%
  3. Allegra: 12 people, 15.19%
  4. Prilosec: 12 people, 15.19%
  5. Zyrtec: 11 people, 13.92%
  6. Benadryl: 11 people, 13.92%
  7. Vitamin D: 9 people, 11.39%
  8. Coumadin: 9 people, 11.39%
  9. Vicodin: 9 people, 11.39%
  10. Xtandi: 8 people, 10.13%

Common side effects people have besides Hot flush *:

  1. Fatigue (feeling of tiredness): 26 people, 32.91%
  2. Fall: 19 people, 24.05%
  3. Rashes (redness): 16 people, 20.25%
  4. Nausea (feeling of having an urge to vomit): 16 people, 20.25%
  5. Headache (pain in head): 15 people, 18.99%
  6. Weakness: 14 people, 17.72%
  7. Hyperhidrosis (abnormally increased sweating): 14 people, 17.72%
  8. Urinary Tract Infection: 14 people, 17.72%
  9. Joint Pain: 14 people, 17.72%
  10. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 13 people, 16.46%

Common conditions people have *:

  1. Prostate Cancer: 8 people, 10.13%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 8.86%
  3. Pain: 6 people, 7.59%
  4. Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 7.59%
  5. Metastases To Bone (cancer spreads to bone): 6 people, 7.59%
  6. Migraine (headache): 6 people, 7.59%
  7. Osteoporosis (bones weak and more likely to break): 6 people, 7.59%
  8. Hypersensitivity: 5 people, 6.33%
  9. High Blood Pressure: 5 people, 6.33%
  10. Multiple Myeloma (cancer of the plasma cells): 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

Do you take Sudafed and have Hot flush?

Check whether Hot flush is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Hot flush and when was it recovered:

Expand to all the drugs that have ingredients of pseudoephedrine hydrochloride:

Alternative drugs to, pros and cons of Sudafed:

Common Sudafed side effects:

Browse all side effects of Sudafed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Hot flush treatments and more:

COVID vaccines that are related to Hot flush:

Common drugs associated with Hot flush:

All the drugs that are associated with Hot flush:

Common conditions associated with Hot flush:

All the conditions that are associated with Hot flush:

How the study uses the data?

The study uses data from the FDA. It is based on pseudoephedrine hydrochloride (the active ingredients of Sudafed) and Sudafed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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