Sulfamethoxazole and Nephritis interstitial - a phase IV clinical study of FDA data


We study 11,829 people who have side effects when taking Sulfamethoxazole. Nephritis interstitial is found, especially among people who are male, 60+ old, also take Crixivan.

The phase IV clinical study analyzes which people take Sulfamethoxazole and have Nephritis interstitial. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2023

11,829 people reported to have side effects when taking Sulfamethoxazole.
Among them, 18 people (0.15%) have Nephritis interstitial.

What is Sulfamethoxazole?

Sulfamethoxazole has active ingredients of sulfamethoxazole. It is used in urinary tract infection. Currently, eHealthMe is studying from 12,042 Sulfamethoxazole users.

What is Nephritis interstitial?

Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules) is found to be associated with 1,008 drugs and 485 conditions by eHealthMe. Currently, we are studying 3,589 people who have Nephritis interstitial.

Number of Sulfamethoxazole and Nephritis interstitial reports submitted per year:

Could Sulfamethoxazole cause Nephritis interstitial?

Gender of people who have Nephritis interstitial when taking Sulfamethoxazole *:

  • female: 41.18 %
  • male: 58.82 %

Age of people who have Nephritis interstitial when taking Sulfamethoxazole *:

  • 0-1: 0.0 %
  • 2-9: 5.88 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 35.29 %
  • 40-49: 17.65 %
  • 50-59: 0.0 %
  • 60+: 41.18 %

Common drugs people take besides Sulfamethoxazole *:

  1. Crixivan: 9 people, 50.00%
  2. Methylprednisolone: 7 people, 38.89%
  3. Lamivudine: 5 people, 27.78%
  4. Didanosine: 4 people, 22.22%
  5. Norvasc: 4 people, 22.22%
  6. Pepcid: 4 people, 22.22%
  7. Acyclovir: 3 people, 16.67%
  8. Zidovudine: 3 people, 16.67%
  9. Famotidine: 3 people, 16.67%
  10. Fluconazole: 3 people, 16.67%

Common side effects people have besides Nephritis interstitial *:

  1. Blood Creatinine Increased: 8 people, 44.44%
  2. Dehydration (dryness resulting from the removal of water): 7 people, 38.89%
  3. Haematuria Present (presence of blood in urine due to trauma): 7 people, 38.89%
  4. Nocardia Infection (a bacterial infection that usually starts in the lungs. it may spread to other organ systems): 7 people, 38.89%
  5. Skin Atrophy (wasting of skin): 6 people, 33.33%
  6. Intertrigo (inflammation (rash) of the body folds (adjacent areas of skin)): 5 people, 27.78%
  7. Rashes (redness): 5 people, 27.78%
  8. Fever: 4 people, 22.22%
  9. Proteinuria Present: 4 people, 22.22%
  10. High Blood Pressure: 3 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Sulfamethoxazole and have Nephritis interstitial?

Check whether Nephritis interstitial is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Sulfamethoxazole side effects by duration, gender and age:

Nephritis interstitial treatments and more:

Common drugs associated with Nephritis interstitial:

All the drugs that are associated with Nephritis interstitial:

Common conditions associated with Nephritis interstitial:

All the conditions that are associated with Nephritis interstitial:

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole (the active ingredients of Sulfamethoxazole) and Sulfamethoxazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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